Extracts of Hypericum, Passiflora and Valeriana are used for the treatment of mild depression and anxiety. We were interested whether a combination of Hypericum and Passiflora exerts comparable effects to Hypericum alone. We used two well-established models for investigating extracts for their anti-depressant activity, namely the effects on synaptic uptake of serotonin and the forced-swimming-t...

BACKGROUND It has been observed that the various part of Baccaurea ramiflora plant is used in rheumatoid arthritis, cellulitis, abscesses, constipation and injuries. This plant also has anticholinergic, hypolipidemic, hypoglycemic, antiviral, antioxidant, diuretic and cytotoxic activities. The present studyaimed to assess the cytotoxic, analgesic, anti-inflammatory, CNS depressant and antidiarr...

Anticonvulsant activity of the methanolic extract of Prosopis Cineraria (Linn) Druce stem barks was studied against maximal electro shock (MES) and Pentylenetetrazole (PTZ) induced convulsions in mice. The extract suppressed hind limb tonic extensions (HLTE) induced by MES and also exhibited Protector Effect in PTZInduced Seizures. In conclusion, the methanolic extract of Prosopis Cineraria (Li...

Isatin, also known as 1H-Indole-2, 3-Dione, is an eight-carbon containing endogenous compound found in nature. Erdmann and Laurent synthesized isatin 1840, before it was discovered It versatile distributed tissues body fluids. Isatins have been detected mammalian tissue, their function a biochemical process modulator has the focus of many debates. The moiety shows some important chemical reacti...

Presynapticand postsynaptic glutamatergic modulation is associated with anti-depressant activity that takes several weeks to reach a maximal full effect [1]. Limiting mood elevating effects after single drug administration may be the result of compensatory synaptic processes [2, 3]. Therefore, using augmentation treatment with agents having presynapticand postsynaptic effects on the glutamaterg...

Mucuna pruriens has been used by native Nigerians as a prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the pharmacological actions of N. sputatrix (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of N. sputatri...