(1) Background: Temporal lobe epilepsy (TLE) is the most common type of epilepsy in adults. It is also the one with the highest percentage of drug-resistance to the current available anti-epileptic drugs (AED). Additionaly, most antiepileptic drugs are only able to control seizures in epileptogenesis, but do not decrease the hippocampal neurodegenerative process. TLE patients have a reduced pop...

Key-words Disease name and synonymes Excluded diseases Diagnostic criteria / definition Differential diagnosis Frequency Clinical description Management including treatment Etiology Diagnostic methods Genetic counselling Unresolved questions References Abstract Lennox-Gastaut syndrome (LGS) belongs to the group of severe childhood epileptic encephalopathies. This disorder is defined as a crypto...

Epilepsy is a common neurodegenerative disease with an increasing morbidity. Clinical treatment of epilepsy includes symptomatic treatment, etiological treatment, surgery and prevention. The aim of the present study was to determine the effects of antiepileptic drugs (AEDs) on serum folate and vitamin B12 in various epileptic patients, and to examine the correlation between these effects and se...

BACKGROUND Despite advances in treating epilepsy, uncontrolled epilepsy continues to be a major clinical problem. Therefore, this work aimed to study the epidemiology of uncontrolled epilepsy in Al-Kharga District, New Valley. METHODS This study was carried out in 3 stages via door-to-door screening of the total population (62,583 persons). All suspected cases of epilepsy were subjected to ca...

BACKGROUND Epilepsy is common in patients with a glioma. Antiepileptic drugs (AEDs) are the mainstay of epilepsy treatment, but may cause side effects and may negatively impact neurocognitive functioning and quality of life. Besides antiepileptic drugs, anti-tumour treatment, which currently consists of surgery, radiotherapy and/or chemotherapy, may contribute to seizure control as well. In gli...

objective: to investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among iranian patients before and after sodium valproate treatment.   patients and methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic epilepsy were recruited. serum antinuclear antibodies (ana), anti-cardiolipin antibodies (acl), a...

The choice of an antiepileptic drug (AED) in patients with epilepsy is mainly based on efficacy and safety of each drug. However, these criteria of drug selection should be further evaluated according to the epileptic syndromes, and adjusted to the sex and age of the patient. Unfortunately, very few studies have been conducted based on these latter criteria. We conducted a survey on the managem...

Objective: Epilepsy is the second most common chronic neurological condition seen by neurologists. It is estimated that there are 55, 00,000 persons with epilepsy in India. So, the present study aims at getting an insight into the type of epileptic seizures prevalent in a tertiary referral teaching Hospital in eastern India, to describe the drug utilization pattern of antiepileptic drugs (AEDs)...

Background: Epilepsy is a chronic condition with an incidence of 4–10/1,000 worldwide, Antiepileptic drugs (AED) in common use are carbamazepine (CBZ), phenytoin (DPH), phenobarbitone (PB), and sodium valproate. The effect of AEDs on the vitamin D metabolism is of considerable value especially in children. There are few clinicians who use prophylactic calcium or vitamin D for patients taking AE...