Objective To assess the safety and efficacy of inebilizumab in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Background The lack approved therapies for NMDAR encephalitis has led to substantial variability treatment. High-quality data is needed guide treatment optimize long-term outcomes recovering patients. Inebilizumab a humanized anti-CD19 monoclonal antibody that ca...

In 2007, a rare form of autoimmune encephalitis was characterized by Dalmau et al. termed as anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis. Although it is more common in young females with ovarian teratomas who often present with psychiatric symptoms for the first time, this case reports a female diagnosed with antiNMDA receptor encephalitis in the absence of a neoplasm and diagno...

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, a recently defined and frequently misdiagnosed disease characterized by psychiatric symptoms, seizures, movement disorders and autonomic dysfunction, has been observed predominantly in young females with ovarian teratoma. Conventional imaging techniques, including computed tomography (CT) and magnetic resonance imaging (MRI), are oft...

Purpose Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is being recognized with increasing frequency among children. Given the paucity of evidence to guide the critical care management of these complex patients, we provide a comprehensive review of the literature with pooled analysis of published case reports and case series. Methods We performed a comprehensive literature search usi...

OBJECTIVE To determine whether distinct single nucleotide polymorphisms (SNPs) within the glutamate receptor ionotropic NMDA 1 gene (GRIN1) are associated with NMDA receptor (NMDAR) encephalitis and whether these same variants are associated with variability in the clinical presentation and course of affected patients. METHODS We performed clinical follow-up on 48 patients with NMDAR encephal...

Antibodies against N-methyl-D-aspartate receptor (NMDAR) are identified in the form of immune-mediated encephalitis in which typical manifestations include neuropsychiatric symptoms, seizures, abnormal movements, dysautonomia and hypoventilation. The authors report two cases of anti-NMDAR encephalitis with different presentations and patterns of progression. The first patient presented with sta...