We studied the mechanism by which complement activated by anti-P1A1 antibody elicits the platelet release reaction. Anti-P1A1 antibody mediates its action through the classic complement pathway, and its effect depends on the concentration of IgG antibody on the platelet surface. At relatively high concentrations of anti-P1A1 antibody the release reaction was mediated by a mechanism in part inde...

Chronic immune thrombocytopenic purpura (ITP) is a syndrome of destructive thrombocytopenia due to autoantibodies against platelet-associated antigens. These antigens are most commonly located on the platelet glycoprotein (GP) IIb/IIIa complex. In the present studies, we show that many platelet-associated anti-GPIIb/IIIa autoantibodies from chronic ITP patients depend on conformationally intact...

The management of acute coronary syndromes (ACSs) among adult patients with severe hemophilia A remains a clinical challenge, due to the use anti-platelet, anti-thrombotic agents and/or revascularization procedures in them. We report here case presented non-ST elevation myocardial infarction (NSTEMI), incidental finding artery aneurysms (CAA), requiring an open-heart surgery. He successfully un...

objective: to determine the effects of pre-injury consumption of anti-platelet agents on the 30-day outcomes of patients with mild traumatic brain injury (tbi). methods: this prospective cohort study was conducted at three general hospitals in tehran, iran between july 2013 and july 2014. the study population included all patients with mild tbi aged over 18 years that medicated with aspirin or ...

Danshen, the dried root of Salvia miltiorrhiza, is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggrega...

Binding of anti-phospholipid antibodies to circulating platelets and its consequences on platelet activation and aggregation was investigated in 11 patients with anti-phospholipid antibodies. Seven patients had mild thrombocytopenia. Nine healthy donors served as controls. Binding to platelets was investigated by performing enzyme-linked immunosorbent assays (ELISAs) with phospholipids as antig...

Low-grade inflammation, endothelial dysfunction, and platelet hyper-reactivity to agonists are associated with an increased risk of cardiovascular events. In vitro and animal studies infer an inverse mechanistic relationship between platelet activation and the production of endothelium-derived nitric oxide and prostacyclin. This concept is supported by evidence of an inverse relationship betwee...

The benefits of anti-platelet therapy in the treatment of acute coronary syndrome (ACS) as an adjunct to percutaneous coronary intervention (PCI) are well established (1,2). However, the appropriate response to resistance of anti-platelet therapy remains undefined. Because universal standards and universal definitions of resistance have not been established, conventional wisdom discourages rout...

Previous phytochemical analysis of methanolic extract of A. malabarica L. has indicated the presence of steroid, flavonoid and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check A. malabarica L for possible antiinflammatory activity by HRBC (Human Red Blood Cell) membrane stabiliza...