We have previously described the antibacterial capacity of protegrin-1 (PG-1), a cysteine-rich, cationic peptide from porcine leukocytes, against Neisseria gonorrhoeae. We now report genetic and biochemical evidence that gonococcal susceptibility to the lethal action of PG-1 and other structurally unrelated antibacterial peptides, including a peptide (LL-37) that is expressed constitutively by ...

The antibacterial activity of silver and cationic surfactant modified smectites from North Patagonian, Argentina, were tested in growth inhibition of Escherichia coli bacteria by the test of susceptibility on solid medium. The exchange reactions were carried out using Ag and hexadecyltrimethylammonium (HDTMA) cations in larger amounts than those conventionally required to form monolayer on the ...

Application of pharmacodynamic principles to antifungal drugs has provided an understanding of the relationship between drug dosing and treatment outcomes similar to that observed in antibacterial pharmacodynamics. Initial observations with triazole pharmacodynamics have correlated with clinical trial results and proved useful for validation of in vitro susceptibility breakpoints. Pharmacodynam...

The purpose of the study was to determine the proportions of multidrug-resistant (MDR) Acinetobacter spp. isolates from the district of Nashik in Western India during the period from 2011-2014. Antibacterial susceptibility testing of isolates from inpatients and outpatients was performed using Kirby-Bauer disc diffusion method to determine inhibitory zone diameters. Proportions of non-susceptib...

The aim of the present study evaluates antibacterial activity garlic extracts on isolates Acinetobacter. A total 100 strains were collected from various samples at MGM hospital in Kamothe, Navi Mumbai. susceptibilities to different antibiotics tested by using Kirby Bauer agar disk diffusion method. Seventy-nine per cent isolated showed resistance least 14 or more and all are multidrug resistant...

INTRODUCTION Dacryocystitis is an infection and an inflammation of the lacrimal sac and is an important cause of ocular morbidity in India. OBJECTIVE To isolate and identify the bacterial patterns associated with dacryocystitis and to determine their antibacterial sensitivity pattern. MATERIALS AND METHODS A total of 100 lacrimal swab materials were subjected to bacterial analysis. Children...

Infectious diseases are the major cause of morbidity and mortality caused by Pseudomonas aeruginosa (P. aeruginosa) and Acinetobacter baumannii (A. baumannii) and have successfully evolved numerous strategies for resisting the action of many antibacterial drugs. They harbor several drug resistant mechanisms such as target alteration, efflux pump, low intrinsic susceptibility and cross-resistanc...