tricalcium phosphate as hydroxyapatite is used as a suspension stabilizer in styrene polymerization process. particle size of tcp plays an essential role in the particles’ size distribution and geometrical form of polystyrene products. as the particle size of tcp is reduced, there will be much better chance to engulf the styrene particles. the higher the number of tcp particles surrounding each...

2. Steinbrink K. T h e case for revislon arthroplasty u ing antibiotic-loaded acrylic cement. Clin Orthop Re1 Res 1990; 261: 19-22. 3. Gerhart TN, Roux RD, Hanff PA, Horowitz GL, Kenshaw AA, Hayes WC. Antibiotic-loaded biodegradable bone crmcnt for prophylaxis and treatment of experimental osteomyelitis in rats. J Orthop Res 19?3; 11: 250-5. 4. Reese RE, Betts RE Antibiotic use. In: Reese KE, B...

Timing of debridement and local antibiotic administration on infection has not been clearly defined. A contaminated critical size rat femur defect model was used to determine if earlier debridement with local antibiotics decreased infection. Defects were inoculated with Staphylococcus aureus. At 2, 6, or 24 hours following contamination, defects were irrigated and debrided then directly closed ...

With their rising benefits, cardiac implantable electronic devices (CIEDs) such as pacemakers and left ventricular assist devices (LVADs) have witnessed a sharp rise in use over the past 50 years. As indications for use broaden, so too does their widespread employment with its attendant rise of CIED infections. Such large numbers of infections have inspired various algorithms mandating treatmen...

We have developed methods for using DNA array technology to probe the entire transcriptome to determine the RNA-binding specificity of ligands. Two methods were investigated. In the first method, the RNA-binding aminoglycoside antibiotic tobramycin was covalently linked to magnetic beads. The beads were bound to human liver mRNA and washed, and specifically bound RNA was eluted, amplified, and ...

The impact of bacterial adherence on antibiotic activity was analyzed with two isogenic strains of Staphylococcus epidermidis that differ in the features of their in vitro biofilm formation. The eradication of bacteria adhering to glass beads by amikacin, levofloxacin, rifampin, or teicoplanin was studied in an animal model and in a pharmacokinetically matched in vitro model. The features of S....

chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle for controlled-release formulations. in this study an enteric-coated capsule containing theophylline-chitosan beads based on 23 factorial designs was prepared as a colon drug delivery system. the theophylline-chitosan gel beads were formulated by adding the drug-contai...

using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. the system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. the system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...

Microbial cells embedded in a self-produced extracellular biofilm matrix cause chronic infections, e. g. by Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. The antibiotic killing of bacteria in biofilms is generally known to be reduced by 100-1000 times relative to planktonic bacteria. This makes such infections difficult to treat. We have therefore proposed that biofilms can b...