A wide range of research activities have been carried out so far on benzimidazole and pyridine derivatives to evaluate their Antiviral, Anticancer, Anticonvulsant, Anthelmintic Activity and many promising results are obtained with respect to the anticancer activity. Out of the various ligands used, the alkylating agents are found to be highly active with respect to cancer chemotherapy. Nitrogen...

soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. however, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 mapk) as the main therapeutic targets were...

This discussion of structure-activity relationships is confined to two or the more important classes of anticancer agentswthe alkylating agents and the antimetaboliteswand to results obtained with these compounds in experimental animal therapy. An attempt is made to point to correlations between the anticancer activity and the structure of these compounds. From these structure-activity correlat...

Cancer is a major global problem and is the second leading cause of mortality in the developed countries.Resistance to current chemotherapeutics and high incidence of adverse effects are the two principal reasons for developing new anticancer agents. Phenylacetamide derivatives can act as potential anticancer agents. Synthesis and screening of 2-(4-Fluorophenyl)-N-phenylacetamide derivatives in...

Silver nanoparticles were synthesized using Cynodon dactylon leaf extract and this study demonstrates the efficacy of biologically synthesized Silver nanoparticles (AgNPs) as anticancer and antibacterial agent. Anticancer activity of the biologically synthesized silver nanoparticles was studied using HEpG-2 cell line. The AgNPs showed dose-dependent cytotoxicity against HEpG-2 cells. Antimicrob...

This discussion of structure-activity relationships is confined to two or the more important classes of anticancer agentswthe alkylating agents and the antimetaboliteswand to results obtained with these compounds in experimental animal therapy. An attempt is made to point to correlations between the anticancer activity and the structure of these compounds. From these structure-activity correlat...

BACKGROUND Darjeeling tea, a most popular variety of black tea, though consumed by the people in different parts of world but its beneficial health effects have not been investigated in details. In this study, the antimutagenic and anticancer effect of Darjeeling tea extract (DTE) has been evaluated. METHODS Antimutagenic activity of the DTE was carried out in two different strains of Salmone...