PURPOSE To report a series of 3 patients with soft contact lens-related Fusarium keratitis. Two of them were treated with the antiamoebic polyhexamethylene biguanide 0.02% (PHMB) in combination with antifungal drugs, and 1 patient was treated with PHMB as sole antifungal regimen. METHODS Chart review of 3 patients treated with PHMB in Fusarium keratitis. Two of them were refractory to the com...

Invasive fungal disease represents a major complication in hematological patients. Antifungal agents are frequently used in hematologic patients for different purposes. In neutropenic patients, antifungal agents may be used as prophylaxis, as empiric or preemptive therapy, or to treat an invasive fungal disease that has been diagnosed. The hematologist must be familiar with the epidemiology, di...

INTRODUCTION Diarrhoea is frequently reported in the ICU. Little is known about diarrhoea incidence and the role of the different risk factors alone or in combination. This prospective observational study aims at determining diarrhoea incidence and risk factors in the first 2 weeks of ICU stay, focusing on the respective contribution of feeding, antibiotics, and antifungal drugs. METHODS Out ...

Antifungal prescription remains a challenge in pregnant women because of uncertainties regarding fetal toxicity and altered maternal pharmacokinetic parameters that may affect efficacy or increase maternal and fetal toxicity. We present updated data reviewing the available knowledge and current recommendations regarding antifungal prescription in pregnancy. Amphotericin B remains the first-choi...

the antimicrobial efficacy of methanol and water extracts of seeds of the plant swietenia macrophylla (family: meliaceae) was evaluated against selected pathogenic bacterial strains (bacillus cereus mtcc 430, klebsiella penumoniae mtcc 109, pseudomonas aeruginosa mtcc 424, escherichia  coli mtcc 443, staphylococcus aureus mtcc 96, salmonella typhimurium mtcc 98, micrococcus luteus mtcc 106) and...

Medically important fungal infections can be broadly classified into superficial surface infections and invasive mycoses (Samaranayake and MacFarlane, 1990; Roemer and Krysan, 2014). Superficial surface infections include mucosal candidiasis, dermatophyte infections whereas invasive mycoses affect sterile body sites such as bloodstream, central nervous system, kidney, lungs, and liver. Rise of ...

Infections caused by Candida albicans, often refractory and with high morbidity and mortality, cause a heavy burden on the public health while the current antifungal drugs are limited and are associated with toxicity and resistance. Many plant-derived molecules including compounds isolated from traditional Chinese medicine (TCM) are reported to have antifungal activity through different targets...

Highly stabilized monodispersed silver nanoparticles (AgNPs) were synthesized by Rhizopus stolonifer and the antifungal efficacy of silver nanoparticles (AgNPs) against Candida sp. were studied. Characterization of biosynthesized nanosilver was made by TEM-EDS and AFM. Minimum Inhibitory Concentration (MIC) of biosynthesized AgNPs, Amphotericin B, and Fluconazole have been studied on pathogenic...