Anincreasing number of patients with marked immunosuppression as a result of transplantation, cancer and infection with Hiy has led to the increased, and widespread use of systemic antifungal agents.1} Currently available treatment is limited to 5-fluorocytosine, amphotericin B and azoles such as fluconazole and itraconazole. However, various problems effect the use of these agents. Among the m...

in order to find the plant extracts with antifungal activity, 18 plant species were screened. in this study, distilled water, methanol, chloroform, aceton and ethanol were employed to obtain crude extract from plant samples. the extracts were tested against sugar beet root rot agents, rhizoctonia solani and phytophthora drechsleri. the inhibitory effect of different extracts was investigated by...

in this study, penicillium digitatum, the causes of green mould disease of orange fruits, were isolated from infected fruit in bam city. antifungal activity of three different plant essential oils eucalyptus camaldulensis, zataria multiflora, myrtus communis at 50, 100, 150 and 200 ppm concentration, have been evaluated. mic (minimum inhibitory concentration) and growth inhibition zone diameter...

Therapeutic drug monitoring of any pharmacologic agent should be considered when there is both significant pharmacokinetic variability and strong, clinically relevant, exposure-effect relationships. Many antifungal drugs exhibit marked variability in drug concentration as a result of inconsistent absorption, metabolism, elimination, or interaction with concomitant medications. For each of the a...

Chlorogenic acid is a polyphenol compound, derived from several fruit and plants. The aim of this study was to assess the in vitro antifungal activity of chlorogenic acid and its mode of action. The results indicate that chlorogenic acid exhibits antifungal activities against certain pathogenic fungi in an energy-independent manner, without any hemolytic effect on human erythrocytes. To elucida...

Background: Candidiasis is one of the most common fungal infections in immunosuppressed patients. The condition is usually treated with local and systemic antifungal agents. Given the antifungal properties of propolis, it appears this natural resin material can be effective in treating this infection. The aim of the present in vitro study was to compare the effect of Iranian propolis with those...

The present study was undertaken to explore the inhibitory effect of cyanobacterial extracts of Nostoc commune FA-103 against the tomato-wilt pathogen, Fusarium oxysporum f. sp. lycopersici. In an optimal medium, cell growth, antifungal activity, and antifungal compound production could be increased 2.7-fold, 4.1-fold, and 13.4-fold, respectively. A crude algal extract had a similar effect as m...

The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

Septic arthritis due to fungal infection is uncommon, but when it does occur it can have a devastating effect. Scedosporium prolificans is an emerging fungal pathogen that appears to have a predilection for bone and cartilaginous surfaces. This fungus is resistant to most commonly prescribed antifungal agents. We report the successful treatment of Scedosporium prolificans septic arthritis with ...

antifungal and antibacterial activity of some heterocystous cyanobacteria from paddy-fields in the north of iran was studied. soil samples were collected from paddy-fields of gillan, mazandaran and golestan provinces and cyanobacteria were isolated. supernatants, methanolic and hexane extracts from biomass of 150 strains of cyanobacteria were isolated and screened against six strains of bacteri...