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PURPOSE To reduce antigenicity of allografts and stimulate their replacement by natural recipient tissues. METHODS Experimental allotransplantation of different tissues (fascias, tendons, derma, fat, etc.) with histological, histochemical, electron microscopical, electron histochemical examination 3, 5, 7, 14, 21, 30, 60, 120, 180 and 360 days postoperatively. RESULTS Allografts of differen...

Cell surface proteins of phase I cultures of Bordetella bronchiseptica strains from various species of animals were compared with those of isogenic phase III cultures by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A protein band with a molecular mass of 74 kilodaltons was found only in various phase I cultures. This protein disappeared in parallel with antigenic modulation and ha...

Abstract Immunotherapies such as checkpoint blockade antibodies to block T cell exhaustion have been successful in several cancers non-small lung cancer and melanoma, but limited others (e.g., pancreatic or prostate carcinomas) owing differences tumor antigenicity. Therefore, quantifying antigenicity is critical for immunotherapies. Our lab has shown that can be encoded a single parameter deriv...

Abstract Background The lack of effective treatment against the highly infectious SARS-CoV-2 has aggravated already catastrophic global health issue. Here, in an attempt to design efficient vaccine, a thorough immunoinformatics approach was followed predict most suitable viral proteins epitopes for building that vaccine . Methods amino acid sequences four structural (S, M, N, E) along with one ...

In the preceding paper it was shown that the attachment of tyrosine, tryptophan or phenylalanine peptides to gelatin converts it into a relatively powerful antigen. The serological specificity of these gelatin derivatives varied according to the nature and the length of the peptides attached. Thus the specificity of polytyrosyl gelatin (10% of tyrosine residues) and polytryptophyl gelatin (25% ...

Backgroung and Aims: L-Asparaginase II is a cornerstone of treatment protocols for acute lymphoblastic leukemia. Only asparaginase II obtained from E. coli K12 and Erwinia chrysanthemi have been used in human as therapeutic drug. The therapeutic effects of asparaginase II from E. coli K12 and Erwinia chrysanthemi is accompanied by side effects. It is desirable to search for other asparaginase I...

AIM This study aims to determine the effect of the stationary rawx, roller, and the suspension cell culture systems on the total virus yield infectivity and antigenicity. MATERIALS AND METHODS Three serotypes of foot and mouth disease virus (FMDV) (serotype A, O and SAT-2) were inoculated separately into baby hamster kidney-21 cell line in rawx, roller, and suspension cultivation systems usin...