The procedure of initial studies to evaluate usefulness of the collected data for performing efficient QSAR analysis of any group of pharmacologically active substances was worked out. Structure-Activity Relationship (SAR) study on the thiazole derivatives with H1-antihistamine activity, the benzothiazole derivatives with H3-antihistamine activity and tetrahydroisoquinoline (TIQ) derivatives wi...

Pollen forecasts are in use everywhere to inform therapeutic decisions for patients with allergic rhinoconjunctivitis (ARC). We exploited data derived from Twitter in order to identify tweets reporting a combination of symptoms consistent with a case definition of ARC and those reporting the name of an antihistamine drug. In order to increase the sensitivity of the system, we applied an algorit...

BACKGROUND Single premedication with antihistamines for radiocontrast media (RCM) hypersensitivity is frequently used in real world at the emergent situation although its efficacy is not proven. OBJECTIVE To evaluate the effect of intravenous antihistamines as a premedication in general population who had experience of mild adverse reactions to iodinated RCM. METHODS A retrospective observa...

Introduction: Febrile seizures (FSs) are caused by the simultaneous consumption of first- and second-generation antihistamines, which prolong process in some cases. Objectives: The present study aimed to evaluate relationship between seizure susceptibility type antihistamines patients with FS. Patients Methods: This retrospective cohort was conducted on 364 children FS admitted Taleghani Hospit...

ketotifen is a potent, safe and long acting antihistamine that is effective in treatment of asthma and its use is believed to causes weight gain and drowsiness. cyproheptadine, an antihistamine, has anticholinergic and antiserotonergic effects, and causes increases of the appetite and weight gain. in this study the effects of different doses of ketotifen and/or cyproheptadine on the appetite an...

Data from a hospital-based drug surveillance programme were used to determine how often benzodiazepine drugs were used in general medical wards. Benzodiazepines were the drugs most commonly used as hypnotics and were given to 32% of these patients. Concomitant use of more than one benzodiazepine drug or of benzodiazepines with other psychoactive drugs was common and often irrational. A series o...

This guideline is a result of a consensus reached during the 19th Asian-Australasian Regional Conference of Dermatology by the Asian Academy of Dermatology and Venereology Study Group in collaboration with the League of Asian Dermatological Societies in 2010. Urticaria has a profound impact on the quality of life in Asia and the need for effective treatment is required. In line with the EAACI/G...

Chronic urticaria (CU) is a common condition faced by many clinicians. CU has been estimated to affect approximately 0.5%-1% of the population, with nearly 20% of sufferers remaining symptomatic 20 years after onset. Antihistamines are the first-line therapy for CU. Unfortunately, nearly half of these patients will fail this first-line therapy and require other medication, including immune resp...

Acute infantile hemorrhagic edema (AIHE) is an uncommon cutaneous leukocytoclastic vasculitis characterized by large purpuric skin lesions, acral edema and fever. In spite of violent onset, spontaneous recovery without any sequelaes occurs within a few weeks. The causes of AIHE are unknown and there is no specific treatment. In this article, we have presented seven cases with AIHE admitted to o...

In the preceding paper of this series (4) it was reported that application of chaulmoogra oil and certain of its derivatives to the skin surface induced phagocytic activity of endothelial cells of the small skin vessels. The same phenomenon could be induced by histamine, as had previously been observed by Jancso (5) and confirmed by Biozzi et al. (1) and by ourselves (2). We attached a certain ...