The striking success of antihistaminic agents such as pyribenzamine, benadryl and several others in controling the nasal turgescence and rhinorrhea of seasonal hay fever, and in relieving the symptoms of urticaria, led to exaggerated hopes of similar results in the treatment of asthma. While the effectiveness of antihistaminic agents has lent considerable support to the role of histamine in all...

Levocabastine is a highly potent and selective H(1)-receptor antagonist specifically developed for topical administration by ocular and nasal routes. The clinical effects of levocabastine occur rapidly and are predominantly due to local antihistaminic effects at the site of application. Clinically, levocabastine is well tolerated with an adverse effect profile comparable with that of sodium cro...

A new in vitro technic for the study of isolated surviving arteries and veins is described. Observations of the reactivity of 21 human and 68 swine coronary arteries to histamine, acetylcholine, l-epinephrine and l-norepinephrine are reported. Histamine and acetylcholine uniformly caused vasoconstriction of the coronary arteries of man and swine. Three potential mechanisms of coronary artery va...

Palmyrah seed haustorium is most beneficial (in human health) with its medicinal properties. It contains various volatile compounds and health benefits, preventing many diseases. The present study was carried out palmyrah to evaluate the through GC-MS analysis using methanolic extract. extract used identify amount of bioactive substances, secondary metabolites, sugars, amino acids, organic fatt...

© 2017 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow A 1‐year‐old girl was brought to our clinic by her parents with the complaint of papulosquamous lesions covered with hemorrhagic crusts on the anterior trunk. The patient had developed erythematous squamous plaques on the scalp, inguinal region, and the face at the age of 3 months. The patient was given a therapy of ...

It was previously studied that the antihistaminic chlorpheniramine elicits a biphasic response on cell growth and regulates polyamine metabolism, as described for polyamines. In part, polyamine effects on macromolecular synthesis and cell growth are attributed to nucleic acid:polyamine interactions. In this work, we have tested the hypothesis of a DNA:chlorpheniramine interaction, using fluorom...