The objective was to study factors related to the changes induced by antihypertensive treatment on oxidative status, antioxidant activities, and reactive oxygen species by-products in whole blood and mononuclear peripheral cells. Eighty-nine hypertensive patients (mean age 46 years, 46 men, average 24-h blood pressure 139/88 mm Hg, body mass index 29) were included. After 3 months of nonrandomi...

Conventional clinic measurement of blood pressure has many deficiencies, among which the most significant are its inability to indicate the duration of drug effect, or the influence of antihypertensive drugs on nocturnal blood pressure. The technique is, therefore, unreliable for assessing antihypertensive drug efficacy, either in clinical practice or hypertension research. Non-invasive 24 h am...

PURPOSE To determine the effect of job insecurity based on repeated measurements on ischemic heart disease (IHD) and on antihypertensive medication. METHODS The study population consists of 12,559 employees aged 18-59 years of the Danish Work Environment Cohort Study. With an open cohort design, data from up to four representative waves were linked to four registers. Poisson regression with t...

Background Antihypertensive drug use is inconsistently associated with the risk of dementia, Alzheimer's disease, cognitive impairment, and cognitive decline. Therefore, we conducted a meta-analysis of available prospective cohort studies to summarize the evidence on the strength of these relationships. Methods Three electronic databases including MedLine, Embase, and the Cochrane Library wer...

OBJECTIVE To characterize hypertension management in an academic family medicine clinic. DESIGN Cross-sectional chart review. SETTING Academic family medicine clinic in Edmonton, Alta. PARTICIPANTS A total of 210 patients with 1 or more visits for hypertension during the previous 3 years. MAIN OUTCOME MEASURES Patient characteristics, current antihypertensive therapies, most recent bloo...

OBJECTIVES To assess the association between angiotensin converting enzyme inhibitors (ACEis) and improvements in the physical function of older adults in response to chronic exercise training. DESIGN Secondary analysis of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study, a multisite randomized clinical trial to evaluate the effects of chronic exercise on the physi...

Obese patients are prone to arterial hypertension, require more antihypertensive medications, and have an increased risk of treatment-resistant arterial hypertension. Obesity-induced neurohumoral activation appears to be involved. The association between obesity and hypertension shows large inter-individual variability, likely through genetic mechanisms. Obesity affects overall cardiovascular a...

BACKGROUND Compliance with antihypertensive medications is essential to the clinical management of hypertension. Poor compliance with antihypertensive medications has often been associated with treatment failure and disease progression. OBJECTIVE To identify patient and prescriber characteristics that may influence compliance with antihypertensive medications. METHOD We used pharmacy record...