Individuals with glucose 6-phosphate dehydrogenase (G6PD) deficiency are at risk for the development of hemolytic anemia when given 8-aminoquinolines (8-AQs), an important class of antimalarial/antiinfective therapeutics. However, there is no suitable animal model that can predict the clinical hemolytic potential of drugs. We developed and validated a human (hu)RBC-SCID mouse model by giving no...

BACKGROUND Community-acquired complicated intraabdominal infections (cIAIs) present problems for clinicians and have substantial impact on hospital resources. Because of the polymicrobial nature of these infections, successful management of cIAIs depends on timely and appropriate use of antisepsis and antiinfective strategies. METHODS The literature pertinent to this article was reviewed. R...

background: in current study, chemical composition and antibacterial activity of leaves and flowers essential oils of origanum vulgare ssp. gracile against four food-borne pathogens including  escherichia coli, listeria monocytogenes, salmonella thyphimurium and staphylococcus aureus were examined. methods: the different organs (leaves and flowers) of o. vulgare ssp. gracile were harvested at f...

introduction: the plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-ht) system on cognitive and non-cognitive behaviors. thus, the purpose of this study is to assess the effects of hippocampal 5-ht4 receptor on memory acquisition deficit induced by harmaline.  methods: harmaline was injected peritoneally, while 5-ht4 receptor agonist (rs...

background: to assess the distribution and resistance of the pathogens responsible for septic arthritis and osteomyelitis over a 10 years period in children admitted to children's medical center hospital, tehran, iran. methods: microbiologic and clinical presentation reports from 145 cases of septic arthritis and osteomyelitis from march 1995 to february 2005 were retrospectively reviewed. resu...

To evaluate the accuracy of computerized algorithms for pinpointing periods of exposure to medications during pregnancy in the absence of data on timing of conception, the authors used data from a population-based sample of nonmalformed infants in the Slone Epidemiology Center Birth Defects Study in 1998-2006 (United States and Canada; N = 3,177). The standard was defined as any antiinfective u...

PURPOSES An abdominal inflammatory focus is the second most often source of sepsis with a high risk of death in surgical intensive care units. By establishing evidence-based bundled strategies the surviving sepsis campaign provided an optimized rapid and continuous treatment of these emergency patients. Hereby the hospital mortality decreased from 35 to 30 %. Sepsis treatment is based on three ...

We assayed the effects of velvet antler (VA) of Formosan sambar deer (Cervus unicolor swinhoei) and its extracts on the anti-infective activity against pathogenic Staphylococcus aureus in vitro and in vivo in this study. In vitro data indicated that the VA extracts stimulated the proliferation of resting splenocytes and macrophages in a dose-dependent manner up to the highest concentration used...