The radiation response of murine L1210 leukemia was exam ined. Radiation dose-survival curves demonstrated that nondividing (resting) leukemic cells and logarithmically proliferating leukemic cells were equally radiosensitive. A radiosensitive state was also demonstrated for 2 drug-altered leukemia cell lines, 1 strain being markedly resistant to antimetabolite therapy and the other having a de...

An enzymatic method for the measurement of methotrexate (MTX) in serum is presented in which the inhibition of the enzyme dihydrofolate reductase by MTX is measured. Reduction of the substrate dihydrofolate by the enzyme and cofactor NADPH is lessened in direct proportion to the amount of MTX present. Measurements can be made in the "therapeutic range" of MTX which corresponds to the 10(-7) to ...

INTRODUCTION Jasmonoids have been found to play important roles in plant growth regulation.1 Recent development of industrial production of ()-methyl jasmonate (MJA, 1) from Nippon Zeon Co., Ltd. made it possible to use MJA as a practical plant growth regulator.2 we have been studying new jasmonoid analogs to develop more active compounds.3 we took notice of the hypothesis that the metabolic in...

http://www.revistadechimie.ro 964 It is established that analogues of natural nucleobases and nucleosides, containing nitrogen atoms have good antimetabolite [1, 2], antiviral, antibacterial [3, 4] antitumor and antimetastatic properties [5]. One of the first compounds obtained, exhibiting good antitumor and antimetabolite activity is 6-azauridine, an analogue of 6azauracil [2]. In recent years...

In a series of 26 species selected from widely differing classes, 1,2-dichloro-4,5-diaminobenzene was toxic to those which did not exhibit a nutritional need for riboflavin plus vitamin B(12). It failed to retard the growth of those which needed both of these vitamins. The compound was conceived as an antimetabolite of 1,2-dimethyl-4,5-diaminobenzene. This latter, which is contained within the ...