Peptoids (oligo N-substituted glycines) are peptide analogues, which can be designed to mimic host antimicrobial peptides, with the advantage that they resistant proteolytic degradation. Few studies on efficacy of peptoids have focused Gram negative anaerobic microbes associated clinical infections, commonly recalcitrant antibiotic treatment. We therefore studied cytotoxicity and antibiofilm ac...

Canavalia gladiata is a perennial ethnomedicinal climber food plant found throughout the World. It shows many therapeutic properties which can be utilized for treatment against human diseases. In this review, we surveyed recent findings on pharmacological and of gladiata. The objective to provide detail analysis active compounds present in species information regarding its activities diseases s...

Background Chronic hepatitis B virus (HBV) infection is a global health threat for which there an urgent need to develop novel therapeutics. Methods Aurintricarboxylic acid (ATA) has been demonstrated with broad-spectrum antimicrobial and antiviral activities. In this study, we implemented ATA treatment in HBV-infected HBV-transfected hepatocytes uncover whether inhibits HBV replication its und...

Singh, S. 2016. Amphiphilic Peptide Interactions with Complex Biological Membranes. Effect of peptide properties on antimicrobial and anti-inflammatory effects. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 216. 64 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9559-6. With increasing problem of resistance development in bacteria against con...

UNLABELLED Antimicrobial peptides offer potential as novel therapeutics to combat food spoilage and poisoning caused by pathogenic and nonpathogenic bacteria. Our previous studies identified the peptide human beta-defensin 3 (HBD3) as a potent antimicrobial agent against a wide range of beer-spoiling bacteria. Thus, HBD3 is an excellent candidate for development as an additive to prevent food a...

The alarming increase in incidence of multidrug-resistant, pathogenic bacteria, the paucity in the discovery of new antibiotic leads, and the resulting public health risk have recently heightened interest in naturally occurring antimicrobial peptides (AMPs) as potential novel therapeutics. [1, 2] Higher organisms are equipped with an innate immune system that allows them to fight invading patho...

introduction: renal colic can be managed by preventing the contraction movements of ureter muscles. by reducing acetylcholine in the nerve terminals, magnesium sulfate could be effective in this regard. the aim of this study is to investigate the effect of magnesium sulfate on acute renal colic pain relief. method: the present study was a double-blind clinical trial in which the patients suffer...

the acute coronary syndrome due to the left main coronary artery (lmca) thrombosis is a clinically rare and catastrophic event.   we describe a young man ( smoker, alcoholic, and drug abuser) with a history of recent surgery and typical chest pain who had non-occlusive lmca thrombosis in coronary angiography. the thrombosis was successfully treated with two 180 µ/kg intracoronary boluses of ept...

Antimicrobial research is being pressured to look for more effective therapeutics for the ever-growing antibiotic-resistant infections, and antimicrobial peptides (AMP) and antimicrobial combinations are promising solutions. This work evaluates colistin-AMP combinations against two major pathogens, Pseudomonas aeruginosa and Staphylococcus aureus, encompassing non- and resistant strains. Colist...