With the impending crisis of antimicrobial resistance, there is an urgent need to develop novel antimicrobials to combat difficult infections and MDR pathogenic microorganisms. DNA replication is essential for cell viability and is therefore an attractive target for antimicrobials. Although several antimicrobials targeting DNA replication proteins have been developed to date, gyrase/topoisomera...

The antimicrobial resistance of Arcobacter (n=174) and Campylobacter (n=215) isolated from broiler carcasses in a US poultry processing plant was examined. For Arcobacter, 93.7% (n=163) were resistant to one or more antimicrobials and 71.8% (n=125) were resistant to two or more antimicrobials. For Campylobacter, 99.5% (n=214) were resistant to one or more antimicrobials and 28.4% (n=61) were re...

Antimicrobials are one of the most widely prescribed classes of therapeutic agents. Although adverse effects of antimicrobials are generally minimal and reversible, serious sequelae can sometimes remain, such as unusual forms of renal failure, acid base disturbance and electrolyte abnormalities. Many antimicrobials, especially vancomycin or aminoglycosides, are associated with development of ac...

In an era of increasing antimicrobial resistance and few antimicrobials in the developmental pipeline, many institutions have developed antimicrobial stewardship programs (ASPs) to help implement evidence-based (EB) strategies for ensuring appropriate utilization of these agents. EB strategies for accomplishing this include formulary restriction with prior authorization. Potential limitations t...

s of papers 51 tissues for antimicrobials. Unfortunately, there is the perception among many consumers that meat, milk and eggs contain high concentrations of drug or hormone residues causing significant health concerns or problems. In fact, foods produced in this country (including poultry) are very safe and meet the highest standards to exclude chemical contaminants. An overview will be prese...

OBJECTIVES Low concentrations of some antibiotics have been reported to stimulate mutagenesis and recombination, which may facilitate bacterial adaptation to different types of stress, including antibiotic pressure. However, the mutagenic effect of most of the currently used antibiotics remains untested. Furthermore, it is known that in many bacteria, including Escherichia coli, stimulation of ...

Antimicrobial usage is common in Asian aquaculture. This study aimed to determine the quality of antimicrobial products used by Vietnamese striped catfish (Pangasianodon hypophthalmus) farmers. Twenty one antimicrobial products (11 products contained a single antimicrobial and 10 products contained a mixture of two different antimicrobials) commonly used by catfish farmers were obtained from so...

INTRODUCTION Nontuberculous mycobacteria are an uncommon cause of septic olecranon bursitis, though cases have increasingly been described in both immunocompromised and immunocompetent hosts. Guidelines recommend a combination of surgical resection and antimicrobials for treatment. This case is the first reported case of nontuberculous mycobacterial olecranon bursitis that resolved without medi...

Bacterial diseases of plants are less prevalent than diseases caused by fungi and viruses. Antimicrobials for prophylactic treatment of bacterial diseases of plants are limited in availability, use, and efficacy, and therapeutic use is largely ineffective. Most applications are by spray treatments in orchards. Monitoring and surveillance for drug resistance are not routinely done. In the United...

AnTIMICRoBIAL resistance is a global health problem of growing concern. In 2010, the World Health organization (WHo) reported that over the past 70 years the use and misuse of antimicrobials in human and animal medicine has led to a ‘relentless rise’ in the number and types of resistant microorganisms. Every use of an antimicrobial can increase the risk of the development of microbial resistanc...