Cyclooxygenase (Cox) is a key enzyme in the biosynthesis of prostaglandins and, as such, is the target of non-steroidal anti-inflammatory drugs (NSAIDs). Two isoforms exist, being expressed constitutively (Cox-1), or inducibly in response to inflammatory mediators (Cox-2). Currently available NSAIDs inhibit both isoforms somewhat equipotently but selective Cox-2 inhibition may eliminate unwante...

Three pineapple cultivars smooth cayenne, Tainung 17, and 19 were processed into flesh, peel, stem. Nine samples analyzed for their proximate compositions bromelain activity existed in water extracts. Pineapple fleshes rich reducing sugars soluble fiber whereas peel stem crude fiber. Stem showed higher (102–247.3 U/mg). All 18 including ethanol extracts quite effective the scavenging ABTS+- DPP...

Abstract Objectives Aside from the activity of gaseous transmitter molecule nitric oxide (NO) and cyclic GMP producing enzyme soluble guanylyl cyclase (sGC) in human penile erectile tissue, intracellular receptor proteins activated by binding have been considered to play a significant role erection process. In animal models, down-regulation GMP-dependent/binding protein kinase I (cGKI) has link...

Metastasis by cancer cells relies upon the acquisition of the ability to evade anoikis, a cell death process elicited by detachment from extracellular matrix (ECM). The molecular mechanisms that ECM-detached cancer cells use to survive are not understood. Striking increases in reactive oxygen species (ROS) occur in ECM-detached mammary epithelial cells, threatening cell viability by inhibiting ...