نتایج جستجو برای: antiproliferative agent
تعداد نتایج: 262054 فیلتر نتایج به سال:
Pancreatic cancer is an aggressive malignancy that is generally refractory to chemotherapy, thus posing experimental and clinical challenges. In this study, the antiproliferative effect of the triterpenoid compound cucurbitacin B was tested in vitro and in vivo against human pancreatic cancer cells. Dose-response studies showed that the drug inhibited 50% growth of seven pancreatic cancer cell ...
Brain metastasis (BM) is increasingly diagnosed in Her2 positive breast cancer (BC) patients. Lack of effective treatment to breast cancer brain metastases (BCBMs) is probably due to inability of the current therapeutic agents to cross the blood-brain barrier. The central nervous system (CNS) response rate in BCBM patients was reported to improve from 2.6%–6% (lapatinib) to 20%–65% (lapatinib i...
Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles possess potent antiproliferative activity against certain cancer cells, similar to the unfluorinated 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495). In "sensitive" cancer cells, DF 203 is metabolized by, can induce expression of, and binds covalently to CYP1A1. Metabolism appears to be essential for its antiproliferative activit...
این پایان نامه به بررسی نقش مثبت یا منفی احساسات روی کارایی عامل های یادگیرنده در یک محیط multi-agent می پردازد. در این راستا مدلی برای عامل های یادگیرنده دارای احساس معرفی می شود. برای بررسی نقش احساسات، یک محیط فرضی multi-agent شبیه سازی شده و حالت های گوناگونی در آن نظر گرفته می شوند. در حالت نخست، کارایی عامل هایی بررسی می شود که دارای احساس نیستند و فقط قابلیت یادگیری دارند. در دومین حالت...
breast cancer is the second main cause of death among women. the use of medicinal plants has been common in many countries since ancient times. the aim of this study was to evaluate the antioxidant and anti-proliferative potential of achillea millefolium l. the antioxidant activity of the aqueous and hydroalcoholic extracts of achillea millefolium l. leaf and flower was measured by dpph and fra...
background: the aim of this study was to investigate the effect of methanolic extract of achillea millefolium l. (mea) on the antiproliferative activity of bleomycin on human prostate cancer and normal skin cells. materials and methods: human prostate cancer cell (du-145) and human non-malignant fibroblast cell (hfff2) were treated with mea at various concentrations ( 20, 100, 500, 1000 and 200...
Terrein is one of the most important biomolecules fungal origin being studied from a medicinal perspective. Secondary metabolites are intermediate products produced during metabolism organisms for large number functions, example, defense and communication signals. From outset, terrein has largely been as an anticancer secondary biomolecule. Aspergillus terreus only source some valuable drugs my...
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