Objectives: A high Helicobacter pylori (H. pylori) seroprevalence has been found in many extragastrointestinal disorders. Moreover, it has been reported that the tuberculosis (TB) risk may be increased in patients with a history of peptic ulcer disease. The aim of this study was to assess the H. pylori seroprevalence in patients with newly diagnosed pulmonary TB, before the initiation of antitu...

The nontuberculosis mycobacteria are often naturally resistant to the conventional antibiotics and to antituberculosis drugs (1–3). In addition, providing advice for the treatment of nontuberculosis is complicated by the variable and changing designations of these organisms, the heterogeneity of the clinical syndromes and patients, and the relative lack of controlled clinical trials (1,2). This...

Background Antituberculosis drugs (ATDs) efficiently combat Mycobacterium tuberculosis either through direct molecular interactions or those of its metabolites. However, a variety of adverse effects have been reported, leading to frequent interruptions of treatment. To investigate the possible metabolic disturbances resulting from antituberculosis (TB) treatment, the uric acid (UA) level of pat...

Numerous studies have reported low concentrations of antituberculosis drugs in tuberculosis (TB) patients, but few studies have examined whether low drug concentrations affect TB treatment response. We examined steady-state plasma concentrations of isoniazid, rifampin, and pyrazinamide at 2 h after the administration of drugs (C(2 h)) among 181 patients with pulmonary tuberculosis in Indonesia ...

Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1-4 exhibited antituberc...

The burden of childhood tuberculosis remains poorly known in the world. The diagnosis is challenging because tuberculosis in children is generally bacteriologically negative. Recent studies have described diagnostic techniques involving molecular biology, advances in the standard treatment and new antituberculosis drugs, however, the diagnosis continues to be based on current clinical data, rad...

BACKGROUND Mortality rates of HIV-infected patients treated for tuberculosis remain high. This study aimed to assess the effect on mortality of immunotherapy with single-dose SRL172 added to standard antituberculosis chemotherapy in such patients. METHODS The double-blind trial enrolled 1229 patients aged 18-60 years, who had never received antiretroviral treatment and who presented with newl...

A 60-year-old male patient on maintenance hemodialysis was started on antituberculosis therapy with isoniazid, rifampin, ethambutol, and pyrazinamide for pulmonary tuberculosis. After 4 weeks of therapy, he developed pruritic lesions in the extremities followed by exfoliation. The lesions progressively spread over the entire body. Lesions resolved after withdrawal of antituberculosis medication...