Dextromethorphan (DEX) is an antitussive agent used in many cough and cold medications, and dextrorphan (DOR) is its metabolite. Owing to their similar structures, optimization of the condition for the chromatography approach, which is in common use for determination, is both demanding and time-consuming. This paper describes a methodology that combines excitation-emission matrix fluorescence s...

Verbascum species, the largest genus of the family Scrophulariaceae, have been used in traditional medicines for centuries in almost all parts of the world. In this paper, the usage, biological activities (antioxidant, anticholinesterase, antiinflammatory, antinociceptive, wound healing, cytotoxic, anticancer, antitumor, immunomodulatory, antimicrobial, antimalarial, anthelmintic, antiviral, an...

This invention is a healthful composition comprising a hot-water extract of the cultivated mycelia of Cordyceps sinensis. The healthful composition of the invention is an oral healthful composition which is highly safe and has excellent cardiotonic, hypotensive, antitussive and anti-fatigue effects. Inventors: Taketomo; Naoki (Tokyo, JP); Tsunoo; Akinobu (Tokyo, JP); Itoh; Hiroyuki (Kanagawa, J...

Experimental ischemia models have shown the antitussive dextromethorphan to be an N-methyl-D-aspartate antagonist with neuroprotective properties. We treated 10 patients with a history of recent stroke or transient ischemic attack with oral dextromethorphan (60 mg q.i.d.) for 3 weeks in a placebo-controlled, double-blind, crossover tolerance study. We documented no clinical evidence of toxicity...

Cough is a primitive reflex typically consisting of an initiating deep inspiration, glottal closure, and an explosive expiration accompanied by a sound. The flow characteristics of cough have been shown to differ between different pulmonary diseases. Cough sounds are generated at the larynx and in the lungs. Modern analysing techniques have also been applied in cough sound studies, and differen...

The objective of this study was to isolate active alkaloids from the Bulbus Fritillariae Cirrhosae (BFC), to evaluate their anti-tussive to find the highly active substance from the BFC for further new drug development. Materials and methods: The BFC was extracted with chloroform: methanol and alkaloids were isolated by phytochemical methods. The anti-tussive activity was investigated using amm...

The primary objective of this study is to evaluate the antitussive, expectorant and anti-inflammatory effects of alkaloids imperialine (I), chuanbeinone (II), verticinone (III), and verticine (IV), which were isolated from the Bulbus Fritillariae Cirrhosae (BFC) using phytochemical method. The results showed that all the alkaloids significantly inhibited cough frequency and increased latent per...