The effect of naloxone, a non-selective opioid antagonist on some anxiolytic and analgesic drugs is reported. Noscapine is an opioid alkaloid with antitussive effect that cannot be antagonized by naloxone. The anxiolytic-like effect of noscapine has been shown in light-dark model and elevated plus maze. In this study the effect of naloxone on anxiolytic effect of noscapine in light-dark model w...

Docetaxel (DOX) is one of the clinically used chemotherapeutic agents for treatment breast cancer, instead its severe side effects. Noscapine, an antitussive opium alkaloid, on other hand, has shown antitumor activity against a number cancers without any significant Since both compounds targeted tubulin, it interesting to see combined effect management cancer. The binding energy -3.49 and -4.18...

26 The caudal nucleus tractus solitarii (NTS) is the main central station of cough-related 27 afferents and a strategic site for the modulation of the cough reflex. The similarities 28 between the characteristics of central processing of nociceptive and cough-related inputs 29 led us to hypothesize that galanin, a neuropeptide implicated in the control of pain, 30 could also be involved in the ...

CONTENTS Summary of key points and recommendations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1256 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1257 Capsaicin and citric acid inhalation cough challenge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1258 Cough induced by ...

Transient receptor potential vanilloid 1 (TRPV1) plays an integral role in modulating the cough reflex, and it is an attractive antitussive drug target. The purpose of this study was to characterize a TRPV1 antagonist, 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), against the guinea pig TRPV1 receptor in vitro followed by a...

Cough is a common symptom of respiratory diseases associated with irritation or inflammation of the airways, and symptomatic antitussive drugs are frequently prescribed to control an abnormal cough reflex. Our aim was to evaluate the effects of moguisteine, a novel, peripheral, nonnarcotic antitussive agent, on airway inflammation induced in guinea-pigs with a variety of stimuli. These stimuli ...