Anxiety disorders have become the number one mental health issue in developed countries. The of people living with anxiety and depressive rose significantly because COVID-19 pandemic. Although generally considered as safe effective, currently available anxiolytic therapy is responsible for numerous side effects addiction. Therefore, there an imperious demand discovering more efficient cheaper n...

Anxiety disorders have become the number one mental health issue in developed countries. The of people living with anxiety and depressive rose significantly because COVID-19 pandemic. Although generally considered as safe effective, currently available anxiolytic therapy is responsible for numerous side effects addiction. Therefore, there an imperious demand discovering more efficient cheaper n...

Tetrahydroprotoberberines (THPBs) are isoquinoline alkaloids isolated from the Chinese herb Corydalis yanhusuo. In the present study, we performed competitive binding assays to examine the binding of l-THBr to neurotransmitter receptors known to be involved in sedation, hypnosis and anxiety. Our results show that l-THBr does not interact with GABAergic receptors but has binding affinities for d...

The aim of the present study was to evaluate the central effects of the phytotherapeutic product-CPV (dry extract of Crataegus oxyacantha, Passiflora incarnata and Valeriana officinalis) in animals models. In order to investigate the psychopharmacological profile of CPV extract, an evaluation toward anxiolytic effect of this extract on the elevated plus-maze (EPM) was carried out. Other effects...

Benzodiazepine receptor agonists are widely prescribed therapeutic agents that alter gamma-aminobutyric acid (GABA)A activity and have anxiolytic effects. Post-operative use of benzodiazepines is a risk factor delirium. Inflammatory conditions the effects benzodiazepine. We investigated effect diazepam, typical benzodiazepine anxiolytic, on changes in emotional behavior mice hole-board test aft...