Trametinib is a MEK1 inhibitor used in the treatment of BRAF V600E or V600K mutated melanoma. Roughly 10% patients develop cardiomyopathy following chronic trametinib exposure. Although described clinically, molecular landscape trametinib-induced heart failure has not been characterized. We hypothesized that promotes widespread transcriptomic changes consistent with drug-induced cardiotoxicity....

INTRODUCTION Cardiovascular disease is classes of diseases or illness that mainly involves blood vessel which include veins, arteries and capillaries or the heart or the both. Etiology for the cardiovascular diseases is diverse but most common etiology is atherosclerosis and hypertension. Most common risk factors that contribute cardiovascular diseases are, Hypertension, Radiation therapy-repor...

X iv :0 71 1. 24 20 v4 [ as tr oph ] 7 M ar 2 00 9 Erratum: ”Tidal Love numbers of neutron stars” (2008, ApJ, 677, 1216) Tanja Hinderer Center for Radiophysics and Space Research, Cornell University, Ithaca, NY 14853 [email protected] There are typographical errors in Eqs. (20) and (23), and some incorrect entries in Table (1). I thank Ryan Lang for pointing these out. Equation (20) should read...

Image processing is an increasingly important aspect for analysis of data from X and γ-ray astrophysics missions. In this paper, I review a method proposed by Kebede (L. W. Kebede 1994, ApJ, 423, 878), and point out an error in the derivation of this method. It turns out that this error is not debilitating – the method still " works " in some sense – but as published is rather sub-optimal, as d...