نتایج جستجو برای: apo e4 polymorphism

تعداد نتایج: 117403  

Journal: :Atherosclerosis 2000
F Schiele D De Bacquer M Vincent-Viry U Beisiegel C Ehnholm A Evans A Kafatos M C Martins S Sans C Sass S Visvikis G De Backer G Siest

As part of the ApoEurope Project, the apolipoprotein E (apo E) serum concentration and polymorphism were determined in 6934 healthy subjects aged 25-64 years recruited in six European countries: Finland; France; Greece; Northern Ireland; Portugal and Spain. Age and sex influenced apo E concentration with concentrations being significantly higher in men than in women for those aged between 25 an...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1991
R A Hegele W C Breckenridge D W Cox G F Maguire J A Little P W Connelly

The genes for apolipoprotein (apo) C-II, a cofactor for activation of lipoprotein lipase, and apo E, a ligand for receptor-mediated uptake of triglyceride-rich lipoproteins, are physically linked on chromosome 19q13.1. In a large Caribbean Caucasian family, several individuals had clinical features of the complete absence of lipoprotein lipase activity and were homozygous for a DNA frameshift m...

Journal: :Human molecular genetics 1998
H G Kraft M Windegger H J Menzel G Utermann

Lipoprotein(a) [Lp(a)] is a quantitative genetic trait in human plasma associated with atherothrombotic disease. The major determinant of Lp(a) concentration is the apolipoprotein(a) [apo(a)] gene locus. Variation in the number of kringle IV repeats (K-IV VNTR) in apo(a) has a direct effect on Lp(a) concentrations but explains only a fraction of the large intra- and inter-population variance in...

2005
Gerald Luc Jean-Marie Bard Dominique Arveiler Alun Evans Jean-Pierre Cambou Annie Bingham Philippe Amouyel Paul Schaffer Jean-Bernard Ruidavets Francois Cambien Jean-Charles Fruchart Pierre Ducimetiere

Human apolipoprotein (apo) E, a polymorphic protein with three common alleles, e2, e3, and e4, plays an important role in lipoprotein metabolism. This article describes the association of this polymorphism with lipids, apolipoproteins, and lipoproteins with a particular regard to lipoprotein particles, as defined by their apolipoprotein content, as well as the risk of myocardial infarction in a...

2005
Gerald Luc Jean-Marie Bard Dominique Arveiler Alun Evans Jean-Pierre Cambou Annie Bingham Philippe Amouyel Paul Schaffer Jean-Bernard Ruidavets Francois Cambien Jean-Charles Fruchart Pierre Ducimetiere

Human apolipoprotein (apo) E, a polymorphic protein with three common alleles, e2, e3, and e4, plays an important role in lipoprotein metabolism. This article describes the association of this polymorphism with lipids, apolipoproteins, and lipoproteins with a particular regard to lipoprotein particles, as defined by their apolipoprotein content, as well as the risk of myocardial infarction in a...

1998
M. O. McCarron

Background and Purpose—Polymorphism of the apolipoprotein E gene (APOE) may influence outcome after traumatic brain injury and intracerebral hemorrhage, with the e4 allele being associated with poorer prognosis. We investigated APOE allele distribution in acute stroke and the effect of the e4 allele on outcome. Methods—APOE genotypes were determined in 714 stroke patients: 640 ischemic stroke a...

Journal: :International journal of epidemiology 1998
C Cobbaert P Mulder

BACKGROUND Differences in serum lipid distribution and mortality from ischaemic heart disease have repeatedly been reported between Belgian northerners and southerners. We investigated whether serum lipoprotein(a) (Lp(a)) and apolipoprotein (apo) E polymorphism were involved. METHODS Fasting serum lipids, apo A-I and B, and Lp(a) levels were examined in randomly selected, 20-39 year old Belgi...

2016
Hao Liu Ping Mao Changhou Xie Wanfu Xie Maode Wang Haitao Jiang

BACKGROUND The relationship between the apolipoprotein E (APOE) polymorphism and intracranial aneurysms has previously only been studied in Russia and Japan but not in Chinese populations. The purpose of this study was to investigate the association between APOE polymorphism and the risk of intracranial aneurysms in a Chinese population. METHODS The study population consisted of 150 intracran...

Journal: :Physiological research 2007
A Kallel M Feki M Elasmi M Souissi H Sanhaji S Omar S Haj Taieb R Jemaa N Kaabachi

Apolipoprotein B (apo B) is the major protein component of LDL, VLDL and chylomicrons. Numerous polymorphisms of the apolipoprotein B gene have been described. Particularly, the insertion/deletion polymorphism located in the coding part of the signal peptide of apo B, associated with modification of lipid concentrations and the risk of cardiovascular disease, has been reported in the general po...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید