نتایج جستجو برای: apobec3
تعداد نتایج: 501 فیلتر نتایج به سال:
Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.
The APOBEC3 family of cytidine deaminases plays critical roles in host innate immunity. These enzymes function as viral DNA mutators capable of restricting an array of virus infections [1]. Given the potent antiviral function of APOBEC3s, strategies to enhance their activity have been suggested as a novel class of antiviral agents. However, recent cancer genome studies have highlighted concerns...
APOBEC3 proteins are restriction factors that induce G→A hypermutation in retroviruses during replication as a result of cytidine deamination of minus-strand DNA transcripts. However, the mechanism of APOBEC inhibition of murine leukemia viruses (MuLVs) does not appear to be G→A hypermutation and is unclear. In this report, the incorporation of mA3 in virions resulted in a loss in virion revers...
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