نتایج جستجو برای: apolipoproteins e
تعداد نتایج: 1023956 فیلتر نتایج به سال:
Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N-8, Stockholm Aging Research Center, Department of Psychology, Stockholm University, Stockholm, Department of Psychology, Department of Radiation Sciences, Clinical Sciences and Psychiatry, Umeå University, Umeå, Sweden and Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Univers...
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Peter Martin, S. Michal Jazwinski, Adam Davey, Robert C. Green, Maurice MacDonald, Jennifer A. Margrett, Ilene C. Siegler, Jonathan Arnold, John L. Woodard, Mary Ann Johnson, Sangkyu Kim, Jianliang Dai, Li Li, Mark A. Batzer, Leonard W. Poon and for the Georgia Centenarian Study Department of Human Development and Family Studies, Iowa State University, Ames, IA, USA; Department of Medicine and ...
BACKGROUND Both family aggregation and apolipoprotein E (APOE) epsilon4 allele are well-known risk factors for dementia, but the relation between these two factors remains unclear. OBJECTIVE To explore whether the risk of dementia and Alzheimer disease (AD) due to a positive family history is explained by APOE genotypes. DESIGN Community-based cohort study. SETTING The Kungsholmen distric...
[PSI+], a non-Mendelian element found in some strains of Saccharomyces cerevisiae, is presumed to be the manifestation of a self-propagating prion conformation of eRF3 (Sup35p). Translation termination factor eRF3 enhances the activity of release factor eRF1 (Sup45p). As predicted by the prion model, overproduction of Sup35p induces the de novo appearance of [PSI+]. However, another non-Mendeli...
While the straightepsilon4 allele of apolipoprotein E ( APOE, gene; ApoE, protein) is widely accepted as a major genetic risk factor for the late onset form of Alzheimer's disease (AD), recent evidence points to variations in ApoE levels as another important factor. We have previously reported that a common variant in the regulatory region of APOE (-491A) is associated with risk for late onset ...
Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also regulates amyloid-β (Aβ) metabolism, aggregation, and deposition. Although earlier work suggests that different affinities of apoE isoforms to Aβ might account for their effects on Aβ clearance, recent studies indicate that...
Background. The "1Western" diet, sex, and apolipoprotein (Apo) E polymorphism have been implicated as codeterminants of lipid levels. Methods and Results. In a retrospective analysis, we evaluated the combined impact of dietary fat, sex, and Apo E phenotype on lipoprotein levels in 67 subjects fed two contrasting, metabolically controlled diets: one a "Western" diet, with a low polyunsaturated ...
Longitudinal data from the MacArthur Study of Successful Aging were used to test for interactions between education and apolipoprotein E (APOE) genotype with respect to time trends in cognitive performance. Interactions between education, APOE-e4 status, and time were found for overall cognitive function, and for subscales measuring memory and naming: The presence of the e4 allele was associate...
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