RATIONALE We previously identified conserved G/C Repressor elements in the promoters of most smooth muscle cell (SMC) marker genes and demonstrated that mutation of this element within the SM22α promoter nearly abrogated repression of this transgene after vascular wire injury or within lesions of ApoE-/- mice. However, the mechanisms regulating the activity of the G/C Repressor are unknown, alt...

The following propositions are true: (1) Let n, m be natural numbers, a be a function from [: Segn, Segm :] into R, and p, q be finite sequences of elements of R. Suppose that (i) dom p = Seg n, (ii) for every natural number i such that i ∈ dom p there exists a finite sequence r of elements of R such that dom r = Segm and p(i) = ∑ r and for every natural number j such that j ∈ dom r holds r(j) ...

The articles [20], [21], [6], [7], [22], [8], [3], [1], [4], [14], [13], [19], [16], [9], [2], [5], [10], [17], [11], [18], [12], and [15] provide the notation and terminology for this paper. Let f be a partial function from C to C. The functor <(f) yielding a partial function from C to R is defined as follows: (Def. 1) dom f = dom<(f) and for every complex number z such that z ∈ dom<(f) holds ...

As a preliminary study of the influence of urban organic matter on the bioavailability of polycyclic aromatic hydrocarbons (PAHs), the effect of different types of dissolved organic matter (DOM) on the bioaccumulation of fluoranthene, pyrene, or benzo[a]pyrene in Daphnia magna was studied. Commercial humic substances, DOM from the aeration basin of a wastewater treatment plant, and highly biode...

Major fraction of marine dissolved organic matter (DOM) is biologically recalcitrant, however, the accumulation mechanism of recalcitrant DOM has not been fully understood. Here, we examine the distributions of humic-like fluorescent DOM, factions of recalcitrant DOM, and the level of apparent oxygen utilization in the Japan Sea. We find linear relationships between these parameters for the dee...

Apoptosis operates to eliminate damaged or potentially dangerous cells. This loss is often compensated by extra proliferation of neighboring cells. Studies in Drosophila imaginal discs suggest that the signal for the additional growth emanates from the dying cells. In particular, it was suggested that the initiator caspase Dronc mediates compensatory proliferation (CP) through Dp53 in wing disc...

objectives: tissue homeostasis is the result of strict regulatory mechanisms, which control self-renewal, differentiation, prevention of premature senescence and apoptosis of stem cells. bmi-1, a polycomb group repressor protein, represses genes that induce cellular senescence and cell death, and can contribute to cancer when improperly expressed. material and methods: bladder tumoral and nont...

The influence of water hardness and dissolved organic matter (DOM) on bioavailability of organic chemicals to Daphnia magna was studied by using benzo[a]pyrene (BaP), pyrene, atrazine, and 3,3',4,4'-tetrachlorobiphenyl (TCB) as model compounds. Two types of DOM were used, namely Lake Kontiolampi, Joensuu, Finland water (KL) and Nordic reference fulvic acid (NoFA) dissolved in artificial freshwa...