Measurements of oxygen profiles across the cornea, aqueous humor, and anterior lens differed from previously calculated values. The aqueous humor oxygen tension in paiticular also differed from previously measured values, being approximately 20 mm. Hg higher. Reasons for these differences are discussed. The tissue oxygen gradients measured confirm the high Qos of lenticular and corneal epitheli...

At a level of 0.01 per cent in isolated, pooled calf aqueous humor, epinephrine bitartrate is converted into a series of pigmented. photoproducts by exposure to near UV light for only a few hours. The brown photoproducts, but not adrenochrome, bind to and alter the electrophoretic mobility of aqueous-humor proteins. The rapidity and mild conditions required for the above-described effects to oc...

The trabecular meshwork (TM) is a filter-like tissue located in the anterior segment of the eye. It is composed of a series of fenestrated beams through which aqueous humor flows to exit the anterior chamber via Schlemm's canal. The primary function of the TM is to regulate the flow of aqueous humor in order to establish intraocular pressure (IOP). Dysregulated aqueous humor outflow causes elev...

PURPOSE To test the hypothesis that an individual shows concordance of aqueous humor flow in the morning and at night in a prospective inpatient fluorophotometry study in healthy subjects. METHODS Flow was measured in each eye every hour between 8 AM and noon and every 2 hours between midnight and 6 AM. Morning and nighttime flows were analyzed for differences between eyes and for differences...

Identifying social gaffes is important for maintaining relationships. Older adults are less able than young to discriminate between socially appropriate and inappropriate behavior in video clips. One open question is how these social appropriateness ratings relate to potential age differences in the perception of what is actually funny or not. In the present study, young, middle-aged, and older...

This study tested a model of the development of incongruity-resolution and nonsense humor during adulthood. Subjects were 4,292 14- to 66-year-old Germans. Twenty jokes and cartoons representing structure-based humor categories of incongruity resolution and nonsense were rated for funniness and aversiveness. Humor structure preferences were also assessed with a direct comparison task. The resul...

A high-pressure liquid chromatography instrument has been used to establish a method for the analyses of ascorbate concentration in aqueous humor. The method detects only the reduced form of ascorbate. The values obtained by this method are very similar to those of the colorimetric method. The ascorbate value in a group of random samples obtained from human glaucoma eyes varied between 3.5 to 3...

In clinical work, the loss of intraocular fluid caused by tonography (dV) is usually calculated according to the formula of Grant and Friedenwald. The validity of this formula has been tested by comparing the dV calculated from known factors in the formula with the dV measured directly on enucleated eyes. Our results show a good correlation between the two methods, especially when the rigidity ...

Epinephrine 2% drops were administered to one eye and a placebo to the fellow eye twice a day for 2 weeks in 18 normal human volunteers. The circadian rhythm of aqueous humor flow was measured by fluorophotometry. Epinephrine (compared with placebo) had no measurable effect on the rate of aqueous flow or the circadian rhythm of aqueous humor flow. These results suggest either that topical appli...

The applanation pneumatonograph combines pneumatic and electronic systems. It is used for measuring intraocular pressure, aqueous humour dynamics, and ocular pulsation. In the present study the PTG and the Goldmann tonometer have been used to measure the intraocular pressure in 40 normal and 40 glaucomatous eyes. It has been found that the results of the two instruments correlate well. The PTG ...