In the United Kingdom, gout represents one of the most common inflammatory arthropathies predominantly managed in the primary care setting. Gout is a red flag indicator for cardiovascular disease and comorbidity. Despite this, there are no incentivised treatment protocols and suboptimal management in the primary care setting is common. A computer based retrospective search at a large inner city...

Proton pump inhibitors are highly effective acid suppressants with decades of use highlighting positive outcomes in millions of patients worldwide, and they offer minimal risk of adverse events. PPIs are considered overutilised when prescribed without an appropriate indication, when patients are left on them 'indefinitely' without appropriate indications and when they are continued after being ...

We report the first case of valvular heart disease due to benfluorex. A 50-year-old woman who had been taking the anorectic agent benfluorex intermittently for one year developed severe fibrosis and regurgitation of the mitral, aortic and tricuspid valves. Clinical, echocardiographic and histopathological findings were analogous to those reported with fenfluramine and dexfenfluramine. The simil...

5 roton pump inhibitors (PPIs) suppress gastric acid secretion by selectively inhibiting the enzyme P hydrogenepotassium adenosine triphosphatase, located in gastric parietal cells. These drugs superseded H2-receptor antagonists as first-line acid suppressants in the 1980s, and their potent effect has revolutionised the management of common upper gastrointestinal (GI) disorders, including gastr...

Antiobesity pharmacotherapy remains the main point of disagreement among both scientists and regulators. This is probably due to small sample sizes, high levels of heterogeneity, and low methodological quality. For many years, Brazil was one of the largest consumers of appetite suppressants worldwide, with evidence of irrational use of this drug class. Therefore, the country was the scene of a ...

P soriasis is a Th1/Th17 chronic immunemediated disease, characterized by increased levels of tumor necrosis factor (TNF)-alfa. TNF-alfa blockers including adalimumab have been widely used to treat immune-mediated diseases such as inflammatory bowel disease, psoriasis, rheumatoid arthritis, and psoriatic arthritis. TNF-alfa plays a central role in the inflammation and cellular immune response a...

OBJECTIVE To identify drugs associated with the complaint of dry mouth. MATERIALS AND METHODS MEDLINE was searched for papers 1980-2002 using keywords, oral, mouth, salivary, drugs, dry mouth and xerostomia, and relevant secondary references were hand-searched. RESULTS Evidence was forthcoming for a number of xerogenic drugs, especially antimuscarinic agents, some sympathomimetic agents, an...

Losing excess body weight is generally not an easy task. One thing that people often struggle with is a very active appetite which causes them to eat more than the body actually needs to sustain itself. It is also one of the things that quickly put people off adopting a healthy lifestyle as they feel that ‘healthy’ suggests some sort of deprivation or starvation! However, appetite control and l...

I've been concerned about my weight all through college. I have what you would call a subclinical eating disorder that never goes so far as anorexia or bulimia. My question is: I have been using diet suppressants (phenylpropanolamine HCL 75mg) bought over the counter for months. Sometimes I don't take them for a week, but usually I take one dose a few times a week. I know it's not recommended t...

Leptospiral organisms have long been presumed to be associated with the presence of equine recurrent uveitis. This project was undertaken to determine the presence of Leptospira spp. in the aqueous humor of horses with uveitis to determine if there was an association with inflammation. Thirty horses were determined to have recurrent uveitis based on clinical evaluation or history. Sixteen horse...