نتایج جستجو برای: arg

تعداد نتایج: 10244  

Journal: :Journal of mass spectrometry : JMS 2012
David R Bush Vicki H Wysocki Patricia Y Scaraffia

It has been demonstrated that argininolysis and uricolysis are involved in the synthesis and excretion of urea in Aedes aegypti female mosquitoes. To further investigate the metabolic regulation of urea in female mosquitoes, it is desirable to have a rapid and efficient method to monitor arginine (Arg) concentration in mosquito excreta. Thus, a procedure currently used for the identification of...

2017
Qinghe Meng Mitchell Cooney Natesh Yepuri Robert N. Cooney

BACKGROUND Specific nutrients like L-arginine (L-Arg) ameliorate intestinal inflammation, however the exact mechanisms of this effect are unclear. We hypothesized the anti-inflammatory effects of L-Arg require active transport and metabolism by inducible nitric oxide synthase (iNOS) to generate nitric oxide (NO). To test this hypothesis we examined the effects of L-Arg, L-Arg transport activity...

2011
Ulla Beckman-Sundh Bo Ek Örjan Zetterqvist Pia Ek

Abstract Introduction. Research in the field of protein-bound phosphohistidine phosphorylation has been hampered by the difficulties in analysis and detection of phosphohistidine. Therefore a screening method was developed primarily for the analysis of phosphohistidine phosphatase 1 (PHPT1) activity. Methods. A highly positively charged substrate, Ac-Val-Arg-Leu-Lys-His-Arg-Lys-Leu-Arg-pNA, con...

2017
Soyoung Shin Subindra Kazi Thapa Ho-Leung Fung

This study was aimed to examine the effect of L-arginine (ARG) exposure on the disposition of asymmetric dimethylarginine (ADMA) in human endothelial cells. Although the role of ADMA as an inhibitor of endothelial nitric oxide synthase (eNOS) is well-recognized, cellular interactions between ARG and ADMA are not well-characterized. EA.hy926 human vascular endothelial cells were exposed to 15N4-...

Journal: :Genetics and molecular research : GMR 2014
L M Dong X Y Zhang H Teng M S Li P Wang

We examined whether the X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism is a risk factor for bladder cancer by conducting a meta-analysis. We searched the Pubmed and Embase databases for study retrieval. This meta-analysis examined 16 case-control studies, including 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on these studies showed n...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001
E J Duell R C Millikan G S Pittman S Winkel R M Lunn C K Tse A Eaton H W Mohrenweiser B Newman D A Bell

X-ray repair cross complementing group 1 (XRCC1) encodes a protein involved in base excision repair. We examined the association of polymorphisms in XRCC1 (codon 194 Arg-->Trp and codon 399 Arg-->Gln) and breast cancer in the Carolina Breast Cancer Study, a population-based case-control study in North Carolina. No association was observed between XRCC1 codon 194 genotype and breast cancer, and ...

2016
A. Alamshah A. K. McGavigan E. Spreckley J. S. Kinsey‐Jones A. Amin I. R. Tough H. C. O'Hara A. Moolla K. Banks R. France G. Hyberg M. Norton W. Cheong A. Lehmann S. R. Bloom H. M. Cox K. G. Murphy

AIMS To investigate the anorectic effect of L-arginine (L-Arg) in rodents. METHODS We investigated the effects of L-Arg on food intake, and the role of the anorectic gut hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), the G-protein-coupled receptor family C group 6 member A (GPRC6A) and the vagus nerve in mediating these effects in rodents. RESULTS Oral gavage of L-Arg reduce...

Journal: :The Journal of biological chemistry 2006
Eva A Norstrøm Sinh Tran Mårten Steen Björn Dahlbäck

Activated protein C inhibits the procoagulant function of activated factor V (FVa) through proteolytic cleavages at Arg-306, Arg-506, and Arg-679. The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa). Protein S has been suggested to annihilate the inhibitory effect of FXa, a proposal that has been challenged. To elucidate the effects of FXa and protein S on the indivi...

2012
S.C.F. Olinto M.G. Adrião T. Castro-Barbosa F. Goulart-Silva M.T. Nunes

The amino acid arginine (Arg) is a recognized secretagogue of growth hormone (GH), and has been shown to induce GH gene expression. Arg is the natural precursor of nitric oxide (NO), which is known to mediate many of the effects of Arg, such as GH secretion. Arg was also shown to increase calcium influx in pituitary cells, which might contribute to its effects on GH secretion. Although the mech...

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