A very short synthesis (5 steps), the crystal structure and resolution of an elaborate, inherently chiral [n](1,6)pyrenophane is reported. The synthesis hinges upon two very productive events: a multicomponent reaction and an unprecedented double-McMurry/valence isomerization/dehydrogenation step. Aromatization reactions are involved in the formation of all four of the rings of the pyrene system.

The reaction of readily accessible 1,1-dialkylhydrazones with commercially available o-(trimethylsilyl)aryl triflates provides a direct one-step route to pharmaceutically important 1-alkylindazoles. The products are obtained in high yields by one-pot NCS-chlorination/aryne annulation or Ac(2)O-acylation/deprotection/aromatization protocols.

Synthetic chain terminators were used to capture the biosynthetic intermediates from a partially reducing iterative type I polyketide synthase, which is integrated into a multimodular biosynthesis enzyme. The off-loaded metabolites clarified the timing of ketoreduction and aromatization in the assembly of the antibiotic micacocidin.

The copper-catalyzed ketenimine formation reaction of 1-(o-acetamidophenyl)propargyl alcohols with various sulfonyl azides is found to undergo a concomitant intramolecular nucleophile attack to generate 1,2-dihydro-2-iminoquinolines after aromatization (via elimination of acetyl and hydroxy groups) and tautomerization. The reaction produces 4-substituted and 3,4-unsubstituted title compounds in...

Abstract The effects of various catalysts on the composition volatile pyrolysis products a plastic waste and biomass mixture (1:1) were studied, by pyrolyzing sample using slow fast heating rate. Various zeolite (β-and Y-zeolites, ZSM-5 FCC) nickel-molybdenum catalyst alumina support applied to find suitable for upgrading quality thermal decomposition mixture. A ratio 2:1 was used in experiment...

The reaction of arylidenemalonodinitriles 1 with 1-arylethylidenemalonodinitriles 2 gives rise to sub­ stituted cyclohexadiene derivatives 3 which then undergo elimination of hydrogen cyanide and afford 3,5-diaryl-2,6-dicyano-aminobenzenes 4. This reac­ tion is a modification of more general dimerization reaction involving ylidenemalonodinitriles synthe­ sized from a variety of ketones. These t...