We systematically assess the current clinical evidence of Gualouxiebaibanxia (GLXBBX) decoction for the treatment of angina pectoris (AP). We included RCTs testing GLXBBX against conventional drugs and GLXBBX combined with conventional drugs versus conventional drugs. 19 RCTs involving 1730 patients were finally identified, and the methodological quality was evaluated as generally low. The resu...

Sixty unselected patients with transient neurological symptoms underwent 24-hour ambulatory electrocardiographic (ECG) monitoring. Haemodynamically significant arrhythmias were observed in 32% of patients, but in only 3% of an age- and sex-matched control group. Nine patients received specific anti-arrhythmic therapy, which resulted in marked symptomatic improvement in each case. It is argued ...

Antiarrhythmic drugs are commonly prescribed cardiac drugs. Due to their receptor mimicry with several of the gastrointestinal tract receptors, they can frequently lead to gastrointestinal side effects. These side effects are the most common reasons for discontinuation of these drugs by the patients. Knowledge of these side effects is important for clinicians that manage antiarrhythmic drugs. T...

Antiarrrhytmics are an important pharmacological class of drugs used in cardiology. The objective of this article is in particular to provide a greater understanding of the mechanisms of action of antiarrhythmics and, consequently, the clinical monitoring of expected outcomes. This article is divided into two parts. The first part, electrophysiology, illustrates the relationship between the act...

Prompt defibrillation after cardiac arrest is necessary to save life. Inexpensive systems providing defibrillation facilities in the community of the Highlands have been devised, one for Inverness town practices, and one for rural practices. Both systems work by 'blind' defibrillation, once the clinical diagnosis of cardiac arrest is confirmed. Acute anti-arrhythmic drugs and intravenous infusi...

Epididymitis is described in a man aged 33 who had been treated with the antiarrhythmic agent, amiodarone. No signs of bacterial infection or anatomical abnormalities were found. Amiodarone as the cause of non-infectious epididymitis has been reported. This additional case stresses the importance of considering an adverse effect of amiodarone treatment as a cause when making a differential diag...

During the past decades there has been a consistent evolution of both surgical and catheter-based techniques for the treatment of stand-alone atrial fibrillation, as alternatives or in combination with anti-arrhythmic drugs. Transcatheter ablation has significantly improved outcomes, despite often requiring multiple procedures and with limited success rates especially in presence of persistent ...

The effects of the antiarrhythmic drug propafenone at c-type kv1.4 channels in Xenopus laevis oocytes were studied with the two-electrode voltage-clamp technique. Defolliculated oocytes (stage V-VI) were injected with transcribed cRNAs of ferret Kv1.4 Delta N channels. During recording, oocytes were continuously perfused with control solution or propafenone. Propafenone decreased the currents d...

22.12 (2002). 66. Beatch GN, Shinagawa K, Johnson BD et al. RSD1235 selectively prolongs atrial refractoriness and terminates AF in dogs with electrically remodeled atria. S. World. Congr. Pharmacol. 24, Abstract 21.11 (2002). 67. Cardiome drug effective for heart patients. Cardiome Pharma Corp. Press Release