Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is high in hematopoietic stem cells and functions in part to protect stem cells from reactive aldehydes and other toxic compounds. In contrast, we found that approximately 25% of all acute myeloid leukemias expressed low or undetectable levels of ALDH1A1 and that this ALDH1A1- subset of leukemias correlates with good prognosis cytogenetics. ALDH1A1-...

for the presentation at the EU-RL-ISS workshop 7-8 October 2013 (Rome, Italy) Arsenic speciation in food – current status on standardization of methods for specific determination of inorganic arsenic Jens J. Sloth, senior scientist, phd National Food Institute,Technical University of Denmark Division of Food Chemistry Mørkhøj Bygade 19, DK-2860 Søborg Email: [email protected] Arsenic (As) is a u...

BACKGROUND It is generally acknowledged that the determination of harmful chemical compounds excreted into saliva is useful for assessing their exposure levels. The aim of the present study was to compare the total arsenic and its species in saliva and urine samples collected from the people residing in an arsenic-contaminated area of China and to further verify the feasibility of using salivar...

BACKGROUND Arsenic-containing carbohydrates (arsenosugars) are common constituents of marine algae, including those species used as human food. The toxicology of these compounds has not been fully evaluated. METHODS Arsenic metabolites in human urine were monitored over a 4-day period after ingestion of a synthetic specimen of arsenosugar. The metabolites were determined by HPLC-inductively c...

Arsenic compounds have been applied at the land surface as pesticides in agricultural areas globally. The purpose of this study was to evaluate the fate of anthropogenic arsenic applications related to agriculture, using arsenic applications on cotton in the southern High Plains (SHP), Texas, as a case study and examining possible linkages with contamination of the underlying Ogallala aquifer i...

This study reports data on arsenic speciation in two green algae species (Cladophora sp. and Chara sp.) and in five aquatic plants (Azolla sp., Myriophyllum aquaticum, Phylloscirpus cf. desserticola, Potamogeton pectinatus, Ruppia filifolia and Zannichellia palustris) from the Loa River Basin in the Atacama Desert (northern Chile). Arsenic content was measured by Mass spectrometry coupled with ...

An analytical speciation method, capable of separating inorganic arsenic (As (V), As (III] and its methylated metabolites (MMAA, DMAA) from common, inert, dietary organoarsenicals, was applied to the determination of arsenic in urine from a variety of workers occupationally exposed to inorganic arsenic compounds. Mean urinary arsenic (As (V) + As (III) + MMAA + DMAA) concentrations ranged from ...

A new method was developed for total arsenic determination in seafood products such as oysters, mussels, tuna fish, and algae. Matrix decomposition and oxidation to arsenate of all the arsenic compounds in the product were completed in 25 min by using a 3-step program of focused microwaves (40-120 W) with nitric and sulfuric acids. Quantitation was performed by hydride generation-atomic fluores...

Arsenic is a trace element and a global contaminant. There are currently large uncertainties associated with our understanding and quantification of the arsenic cycles in the global environment. This study proposes a research framework where the major anthropogenic processes affecting anthropogenic arsenic cycles (AACs) are identified. A characteristic of this framework is that it divides AACs ...