Background: Arsenic as a heavy metal exerts malformation and changes in the reproductive system of men via induction of oxidative stress. We sought to investigate the impact of Vitamin C (Vit C), as a potent antioxidant, on sperm quality and testicular tissue in mice that received sodium arsenite. Methods and materials: NMRI mice were classified into four groups: control, sodium arsenite (7 mg...

Background & Aims: Sodium arsenite causes oxidative stress and endocrine disorders in the reproductive system. The aim was to investigate the protective role of curcumin as an antioxidant on the seminal vesicle tissue in adult mice treated with sodium arsenite. Materials & Methods: Adult male Naval Medical Research Institute (NMRI) mice were randomly divided into 5 groups (six mice per group) ...

We describe the results of a study designed to identify cDNAs encoding Ca2+-transporting ATPases and other cation-transporting ATPases of the aspartylphosphate class. Rat brain, kidney, and stomach cDNA libraries were screened with an oligonucleotide hybridization probe corresponding to a 23-amino acid sequence from part of the ATP-binding site of the sarcoplasmic reticulum Ca-ATPase. This proc...

The present paper examines the ultrastructure of the sarcoplasmic recitulum (SR) and the T system in the striated muscle of the lamprey. The pyroantimonate method was used to visualise the sites of intracellular calcium localisation. Characteristic for the muscle studied are the presence of numerous intricately shaped invaginations on the surface membrane of muscle fibres and peripheral contact...

Prions are unconventional infectious agents composed exclusively of misfolded prion protein (PrP(Sc)), which transmits the disease by propagating its abnormal conformation to the cellular prion protein (PrP(C)). A key characteristic of prions is their species barrier, by which prions from one species can only infect a limited number of other species. Here, we report the generation of infectious...

V. Structure and Function of Sarcoplasmic Reticulum Proteins . . . . . . . . . . . . . . . . . . . . . . 77 A. Major Protein Components . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 1. Ca + Mg ATPase. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 2. Calsequestrin . . . . . . . . . . . . . . . . . . . . ....