نتایج جستجو برای: artemisinins
تعداد نتایج: 777 فیلتر نتایج به سال:
Artemisinins are safely used in the combination therapy for uncomplicated malaria, but their employment during pregnancy is still controversial. In fact, animal studies reported that the active metabolite, dihydroartemisinin (DHA), causes embryonic erythrocytes depletion, when the treatment is performed during a critical period of time. The present study investigates the effect of DHA on human ...
Oxidation of Erythrocytes Enhance the Production of Reactive Species in the Presence of Artemisinins
Structure-Activity-Relationship (SAR) of Artemisinins on some Biological Systems in Male Guinea Pigs
Assessment of in vitro susceptibility is a fundamental component of antimalarial surveillance studies, but wide variations in the measurement of parasite growth and the calculation of inhibitory constants make comparisons of data from different laboratories difficult. Here we describe a Web-based, high-throughput in vitro analysis and reporting tool (IVART) generating inhibitory constants for l...
Understanding the mode of action antimalarials is central to optimizing their use and discovery new therapeutics. Currently used belong a limited series chemical structures mechanisms are coutinuously debated. Whereas involvement reactive species that in turn kill parasites sensitive oxidative stress, accepted for artemisinins, little known about generation such case quinolines or hydroxynaphto...
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