A full-length cDNA encoding a novel human protein was cloned from placenta cDNA. The corresponding 1542 amino acid protein sequence was termed `pregnancy-associated plasma protein-E' (PAPP-E) as it shows a 62% homology to the human pregnancy-associated plasma protein-A (PAPP-A) that is a diagnostic marker for trisomies, especially Down syndrome. The conserved domain structure contains five moti...

Pregnancy-associated plasma protein A (PAPP-A) is a biomarker routinely used in screening for Down syndrome in the first trimester of pregnancy. It is also present in very small amounts in men and non-pregnant women. PAPP-A is a key regulator of local insulin-like growth factor (IGF) bioavailability - IGFs are essential for normal body size during fetal development, but they are associated with...

The effects of dietary supplementation of garlic (Allium sativum) extract on the growth and disease resistance of African catfish, Clarias gariepinus was evaluated. Also in-vitro evaluation of susceptibility of fish-borne multidrug resistant (MDR) pathogenic bacteria to aqueous extract of garlic was done. Aqueous garlic extract exhibited inhibitory activity against MDR bacteria and the degree o...

Background: The aim of our study was to determine the association low levels pregnancy associated plasma protein-A (PAPP-A) estimated at 11-13+6weeks gestation with fetal growth restriction (FGR).Methods: A prospective observational a total 203 pregnant women PAPP-A were followed up and outcome data collected childbirth.Results: incidence FGR 7.3%. significant found between MoM (≤0.49) (p=0.000...

The immune substances or antibodies do not occur free in the blood, but are found associated with the proteins of the serum or plasma. With certain phenomena in the combination of immune body and antigen, the behavior commonly observed may be a function rather of the associated protein than of the immune body itself. "Protective" or "sensitizing" colloid effects on cell suspensions are brought ...

For more than a decade, pregnancy-associated plasma protein-A (PAPP-A) has been examined for its relation to acute coronary syndrome (ACS) and the vulnerable plaque. This review summarizes the current knowledge of plasma PAPP-A in relation to nonpregnant individuals focusing on patients with ACS, discusses its use as a possible biomarker for diagnosis and prognosis in ACS, briefly describes the...

Labeled plasma proteins are produced by administering to dogs the amino acid lysine synthesized with heavy nitrogen. Such labeled proteins are apparently indistinguishable biologically from proteins of normal isotope concentration. Labeled plasma proteins, as plasma, injected into normal dogs pass out of the blood stream at an initially rapid but constantly decreasing non-logarithmic rate. This...