Background Diabetic retinopathy (DR) is deemed a microangiopathy and neurodegenerative disorder, which primary reason of visual impairment in the world. Ferritinophagy critical regulator ferroptosis has vital part etiopathogenesis DR. Nevertheless, its molecular mechanism DR remains to be expounded. Methods The GSE146615 dataset was adopted identify ferritinophagy-related differentially express...

Autophagy is a highly regulated pathway that selectively degrades cellular constituents such as protein aggregates and excessive or damaged organelles. This transport route is characterized by engulfment of the targeted cargo by autophagosomes. The formation of these double-membrane vesicles requires the covalent conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine (PE). H...

The highly conserved self-degradation pathway known as autophagy plays important roles in regulating T lymphocyte homeostasis. Recently, we found that T lymphocytes lacking the autophagy-related gene Atg5 or Atg7 have defective survival and contain expanded mitochondria and endoplasmic reticulum (ER); however, whether these defects are caused by impaired autophagy or by defects in their autopha...