Mutations in the Ataxia-telangiectasia mutated (ATM) gene are frequently found in human cancers, including non-small cell lung cancer (NSCLC). Loss of ATM function confers sensitivity to ionising radiation (IR) and topoisomerase inhibitors and may thus define a subset of cancer patients that could get increased benefit from these therapies. In this study, we evaluated the phenotypic consequence...

Individuals carrying mutations at both ataxia telangiectasia mutated (ATM) gene alleles reportedly have increased plasma cholesterol and triglyceride levels. Previous studies have demonstrated that defective ATM function promotes atherosclerosis. We previously demonstrated that ATM facilitates the clearance of plasma apolipoprotein (Apo)E-deficient, ApoB48-containing (E(-)/B(48)) lipoproteins i...

This paper describes the design and implementation of a Graphical User Interface (GUI) for the layered network topology and the connections in an Asynchronous Transfer Mode (ATM) network managed by the ATM Network Management System (NMS). There are physical and logical networks in an ATM network. In addition, the ATM connections, which are ATM Permanent Virtual Connections (PVCs), have two kind...

AIMS The gene mutated in ataxia-telangiectasia (A-T), designated ATM (for "A-T mutated"), is believed to be associated with an increased risk of developing breast cancer. Most patients with A-T have null mutations of the ATM gene that appear to give rise to a truncated nonfunctional ATM protein. Therefore, the increased risk of breast cancer reported in A-T heterozygotes appears to be the resul...

ATM abnormalities are frequent in chronic lymphocytic leukemia and represent an important prognostic factor. Sole 11q deletion does not result in ATM inactivation by contrast to biallelic defects involving mutations. Therefore, the analysis of ATM mutations and their functional impact is crucial. In this study, we analyzed ATM mutations in predominantly high-risk patients using: i) resequencing...

Here we examine the function of ATM and ATR at telomeres in Arabidopsis. Although plants lacking ATM or ATR display wild-type telomere length homeostasis, chromosome end protection is compromised in atm atr mutants. Moreover, atm tert Arabidopsis experience an abrupt, early onset of genome instability, arguing that ATM is required for protection of short telomeres. ATR, by contrast, is required...

This document gives an overview of Voice Over ATM/Voice Telephony Over ATM (VTOA). It concentrates on various design considerations that need to be addressed while setting up a voice supporting ATM network. It discusses the standards that are getting evolved thanks to the works of ATM Forum. The document ends with brief description of some of the products currently available for VTOA. See Also:...

This paper discusses some security issues of `Classical IP over ATM' networks. After analyzing new threats to IP networks based on ATM, security mechanisms to protect these networks are introduced. The integration of rewalls into ATM networks requires additional considerations. We conclude that careful con guration of ATM switches and ATM services can provide some level of protection against sp...

The Multiprotocol Label Switching (MPLS) Architecture [1] discusses a way in which Asynchronous Transfer Mode (ATM) switches may be used as Label Switching Routers. The ATM switches run network layer routing algorithms (such as Open Shortest Path First (OSPF), Intermediate System to Intermediate System (IS-IS), etc.), and their data forwarding is based on the results of these routing algorithms...