Differences in the expression and function of the organic anion transporting polypeptide (OATP) transporters contribute to interindividual variability in atorvastatin clearance. However, the importance of the bile acid transporter sodium taurocholate cotransporting polypeptide (NTCP, SLC10A1) in atorvastatin uptake clearance (CLupt) is not yet clarified. To elucidate this issue, we investigated...

We directly evaluate the safety and dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase inhibitor atorvastatin (X-tor) and simvastatin (Zocor) in hypercholesterolemic patients. Fifty hyperlipidemia patients between the ages of 20 and 75 years with baseline of low-density-lipoprotein (LDL) cholesterol (>160 mg/dl) and triglycerides (>400 mg/dl) received once-daily dosin...

Macrophage-derived lipases are associated with atherosclerosis in human and animal studies. Despite numerous non-lipid-lowering effects of statins, their effect on macrophage LPL and endothelial lipase (EL) expression has not been investigated. In the present study, atorvastatin and simvastatin dose-dependently decreased LPL and EL expression as well as Rho, liver X receptor alpha (LXRalpha), a...

Volume 1(2) March-April 2013 Page 244 SIMULTANEOUS ESTIMATION OF OLMESARTAN AND ATORVASTATIN IN BULK AND FROMULATION BY USING UV SPECTROSCOPY AND RP-HPLC Revanth Reddy B * , Aravind G Nimra college of pharmacy, Vijayawada *Corresponding author: E.mail: [email protected] ABSTRACT Simple, rapid and accurate UV Spectroscopic (Simultaneous Equation method and First order derivative method) a...

BACKGROUND & AIMS Occasional risk of serious liver dysfunction and autoimmune hepatitis during atorvastatin therapy has been reported. We compared the risk of hepatotoxicity in atorvastatin relative to simvastatin treatment. METHODS The UK GPRD identified patients with a first prescription for simvastatin [164,407] or atorvastatin [76,411] between 1997 and 2006, but with no prior record of li...

OBJECTIVE The Use of Rosuvastatin versus Atorvastatin iN type 2 diabetes mellitUS (URANUS) study compared rosuvastatin with atorvastatin for the reduction of low-density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes. METHODS After a 6-week dietary run-in, patients aged > or = 18 years with type 2 diabetes and LDL-C > or = 3.3 mmol/L were randomised to double-blind treatment...

3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins), are effective serum cholesterol-lowering agents which also have anti-inflammatory properties. The objective of this study was to evaluate the effect of atorvastatin on bronchial hyperresponsiveness. Adult patients (age 14 to 65 years) with bronchial hyperresponsiveness (BHR) diagnosis based on the spirometry with methacholine challe...

OBJECTIVE To review the efficacy and safety of atorvastatin in the treatment of dyslipidemias. DATA SOURCES A MEDLINE search (January 1960-April 1998), Current Contents search, additional references listed in articles, and unpublished data obtained from the manufacturer were used to identify data from scientific literature. Studies evaluating atorvastatin (i.e., abstracts, clinical trials, pr...

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2016;5(S1) tau.amegroups.com profile following atorvastatin treatment. Results: Atorvastatin treatment of PC3 cells for 24 h increased the expression of GFP-LC3-II by >25% and expression continued for >72 h, while apoptosis was not significantly induced within this time period. Four genes associated with the autopha...

Aminoglycosides are still widely used for treatment of gram-negative sepsis in critically ill patients. The most reported electrolyte abnormalities related to these drugs are hypokalemia, hypomagnesemia, and hypocalcemia.In this study potential benefit of atorvastatin in prevention of amikacin-induced electrolytes imbalances has been evaluated. In this trial 44 patients were assigned to the ato...