Ammonia (NH3) is produced industrially by the Haber–Bosch process from dinitrogen (N2) and dihydrogen (H2) using high temperature pressure with an iron catalyst. In contrast to extreme conditions used in process, biology has evolved nitrogenase enzymes, which operate at ambient pressure. biological settings, requires large amounts of energy form ATP, least 13 GJ ton−1 ammonia. 2016, Brown et al...

Introduction: Oxidative stress can impair the antioxidant protective capacity of the body, which is associated with decreased capacity of the body's internal defense system. There are some evidences that training and pumpkin seed (PS) consumption by different mechanisms have a protective effect on myocardial tissue by inhibiting oxidative stress. The aim of the present study was to investigate ...

Objetivo. Determinar la concordancia entre cinco criterios diagnósticos de síndrome metabólico (SM) adolescentes residentes una zona altoandina del Perú. Materiales y métodos. Se realizó un estudio transversal con datos secundarios intervención en dos escuelas públicas el año 2019. Participaron 397 que residen ciudad Cajamarca ubicada región andina aplicaron diagnósticos: Third Adult Treatment ...

Introduction: Refractory/unexplained chronic cough (RUCC) is a highly prevalent debilitating condition. The characteristics of RUCC suggest neuronal excitability. biological mechanisms leading to this in humans are uncertain but thought involve changes both the peripheral and central nervous system. Efficacy P2X purinoceptor 3 (P2X3) antagonists suggests role for extracellular aden...

Diverse effects of Ba^(2+) and Co^(2+) on fura-2 fluorescence ratio signals (FR, F350/F380) were examined in cultured bovine aortic endothelial cells (BAECs). ATP (3 ?M) induced FR oscillations normal Ca^(2+)-containing solutions. Co^(2+), but not Ba^(2+), inhibited ATP-induced oscillations. In Ca^(2+)-free solutions, 3 ?M only elicited a single transient. When replaced Ca^(2+) the perfusate, p...

We experimentally showed that biological molecular motor F$_1$-ATPase (F$_1$) implements an optimal rectification mechanism. F$_1$ hardly suppresses adenosine triphosphate (ATP) synthesis, which is the F$_1$'s physiological role while inhibiting unfavorable hydrolysis of ATP. This a high contrast to simple ratchet model, where inhibition backward current inevitably accompanied by suppression fo...

Automated Theorem Proving (ATP) systems search for aproof in a rapidly growing space of possibilities. Heuristicshave profound impact on search, and ATP makeheavy use heuristics. This work uses reinforcement learn-ing to learn metaheuristic that decides which heuristic useat each step proof the E system. Proximalpolicy optimization is used dynamically select heuristicfrom fixed set, based curre...

Allosteric inhibitors of Abl kinase are being explored in the clinic, often combination with ATP-site kinase. However, there conflicting data on whether both ATP-competitive and myristoyl-site allosteric can simultaneously bind Here, we determine is synergy or antagonism between Abl. We observe that clinical not synergistic ABL inhibitors, however, conformation-selective modulate global conform...