Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel in the ATP binding cassette (ABC) transporter family. Like other ABC transporters, it can hydrolyze ATP. Yet while ATP hydrolysis influences channel gating, it has long seemed puzzling that CFTR would require this reaction because anions flow passively through CFTR. Moreover, no other ion channel is known to require ...

Multidrug resistance (MDR), as is well known, regarded the primary factor in cancer therapy failure. A common mechanism of MDR anticancer drugs expression P-glycoprotein (P-gp), a class ATP-dependent membrane transport efflux pumps called adenosine triphosphate (ATP)-binding cassette (ABC) transporters. It xenobiotics outside cell and plays part typical physiological detoxification host defense...