A 40-year-old woman presents to the clinic with multiple excoriated lesions over her chest, arms, abdomen, and upper back (Figure 1, Figure 2). The lesions have been present for many years; a few of them show signs of recent bleeding. She denies any history of itching, insect bites, exposure to new medications or jewelry, allergies, recent change in medications, travel, or intravenous drug abus...

Epidermolysis bullosa is a group of mechano-bullous genetic disorders caused by mutations in the genes encoding structural proteins of the skin. Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene encoding collagen VII, the main constituent of anchoring fibrils. In this group, there are autosomal dominant and recessive inheritances. The pre-tibial form is characterized by...

Two patients who developed localised radiation retinopathy many years after brachytherapy for retinoblastoma are described. In both patients extracapsular cataract extraction and YAG laser capsulotomy were followed by preretinal and vitreous haemorrhage and in one patient there was deterioration of existing radiation retinopathy with macular oedema. Premacular and vitreous haemorrhage occurred ...

Fig 1. Painful ulcers with eschars and granulation tissue on right arch of foot before first platelet-rich plasma therapy. L ivedoid vasculopathy is a chronic disorder diagnosed based on clinical features such as cutaneous ulcers, atrophic, stellate scars with peripheral telangiectasis and hyperpigmentation. Platelet-rich plasma (PRP) therapy has been successfully used in the treatment of vario...

Lupus erythematosus panniculitis (profundus), a rare variant of chronic panniculitis, sometimes develops during the course of discoid lupus erythematosus or systemic lupus erythematosus. A 61-year-old woman had suffered from autoimmune hepatitis type I for 5 years. Prednisolone had been administered as maintenance therapy and her hepatitis had been well controlled. However, asymptomatic erythem...

© 2010 The Authors. doi: 10.2340/00015555-0835 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 Livedo vasculopathy (LV) is a chronic recurrent disease affecting the lower extremities, clinically developing livedo reticularis, purpuric macules, painful ulcers, hyperpigmentation and atrophic scars (1). Histopathologically, there are segmental hyalinization and thrombosis of ...

A 17-year-old male presented with multiple linear distributed erythema and papules which first appeared since birth. The erythema was fragile, easily traumatized, and often healed with hypopigmented atrophic scars. The right first and second fingers and nails were hypoplastic. Generalized linear or whorled hyperpigmented patches gradually developed and multiple papillomatous papules emerged dur...

Necrobiosis lipoidica (NL) is a cutaneous disease entity that typically manifests as atrophic yellow plaques with telangiectasias on the anterior tibial region. Although NL is commonly associated with diabetes mellitus, the role of trauma in disease development is less commonly emphasized. The relationship between NL and the Köbner phenomenon has been established, as a few cases of NL occurring...

Livedoid vasculopathy is a skin disease that occludes the blood vessels of the dermis. It has a pauciinflammatory or non-inflammatory nature. It is characterized by the presence of macular or papular, erythematous-purpuric lesions affecting the legs, especially the ankles and feet, and producing intensely painful ulcerations, which cause white atrophic scars called "atrophie blanche". This revi...

Striae distensae are linear dermal scars, accompanied by overlying epidermal atrophy, and can result from rapid stretching of the skin associated with rapid growth and weight fluctuations, as well as hormonal changes associated with puberty, pregnancy, body building, and hormone replacement therapy. 1,2 Typically forming perpendicular to the direction of skin tension lines, younger striae diste...