BACKGROUND Many women undergoing cervical screening as part of a national South African screening programme may be positive for HIV. The performance of liquid-based cytology (LBC) on samples from HIV-positive women needs to be determined. OBJECTIVES The performance of the Cellslide® automated LBC system was evaluated as a possible alternative to conventional cytology in a national cervical ca...

We studied interobserver variability in the proportions of human papillomavirus (HPV)-positive results for atypical squamous cells of undetermined significance (ASCUS) and atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) diagnoses among 5 pathologists from the me laboratory during a 2-year period. These proportions were compared with individual patholog...

LEEP conization has become the treatment of choice in patients presenting with high grade intraepithelial lesions (HSILs), especially in cases with negative surgical margins. However, surveillance after such treatment is necessary due to the potential for recurrence. To evaluate the recurrent rate in patients with negative surgical margins after HSIL treatment with LEEP, the medical records of ...

This study compares Xpert® HPV and Hybrid Capture® 2 High-Risk HPV DNA Test™ (hc2) for the detection of high-risk HPV infection in cervical smears. Papanicolaou smears with atypical squamous cells of undetermined significance (ASC-US) constituted the study specimens. Of the 168 ASC-US samples, 134 (79.8%) were from Saudi patients. The hc2 test was positive in 33 (19.6%) of the total patients, 2...

NLIKE the better-known eight-spored species of Neurospora, N . tetrasperma usually produces asci with only four ascospores; each ascospore contains nuclei derived from two of the four meiotic products and is usually heterokaryotic for the mating type alleles. DODGE (1939) showed that eight-spored asci also occurred in N . tetrasperma, in crosses heterozygous for the pleiotropic gene E. Such cro...

OBJECTIVE We examined the accuracy of the Papanicolaou (Pap) test among women with and women at high risk for human immunodeficiency virus (HIV) infection. METHODS Pap test results and colposcopy findings were compared for 189 HIV-infected women and 95 HIV-uninfected women from the Baltimore HIV Epidemiology Research (HER) study site who were followed up semiannually from 1993 through 1999. C...