Learning from complex data with imbalanced label distribution is a challenging problem, especially when the data/label form structure, such as linearchain or tree-like. The widely-used training methods, such as maximum-likelihood and maximum labelwise accuracy, do not work well on imbalanced structured data. To model the complex relationship between the data and the structured label, we present...

Confidence measure plays an important role in keyword spotting. To enhance the effectiveness of the confidence measure, we propose a novel method which improves the performance of keyword spotting by directly maximizing the area under the ROC curve (AUC). Firstly, we approximate the AUC as an objective function with the weighted mean confidence measure. Then, we optimize the objective function ...

OBJECTIVE This study aims to explore the application of actual carboplatin in carboplatin plus pemetrexed regimen as first-line treatment for advanced lung adenocarcinoma, and to determine the recommended dose of carboplatin for Chinese populations. METHODS From January 2014 to April 2016, 151 advanced lung adenocarcinoma patients who received carboplatin and pemetrexed (500 mg/m2 ) were incl...

BACKGROUND We aimed to evaluate whether area under the curve (AUC) analysis of pharmacodynamic data can be used to compare pharmacokinetic models taken from the literature, during a target controlled infusion (TCI) of rocuronium. METHODS Seventy-two patients scheduled for orthopaedic surgery received a TCI of rocuronium (Stanpump) based on one of four pharmacokinetic models: those described b...

the objective of the present study was to evaluate the pharmacokinetic parameters and bioavailability of a selective histamine (h1)-receptor antagonist, cetirizine hydrochloride (ctz), following administration of a single oral dose of the drug. the properties of a test compound were compared with those of a reference product in a randomized cross-over study in 12 volunteers. blood samples were ...

The goal of this study is to investigate the value of tau phosphorylated at threonine 181 (P-tau181P) in the Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker panel for differential dementia diagnosis in autopsy confirmed AD and non-AD patients. The study population consisted of 140 autopsy confirmed AD and 77 autopsy confirmed non-AD dementia patients. CSF concentrations of amyloid-...

BACKGROUND To date, fasting state- and different oral glucose tolerance test (OGTT)-derived measures are used to estimate insulin release with reasonable effort in large human cohorts required, e.g., for genetic studies. Here, we evaluated twelve common (or recently introduced) fasting state-/OGTT-derived indices for their suitability to detect genetically determined β-cell dysfunction. METHO...