We developed a method to estimate genotype-specific average relative mortality risk, R, from genotype distributions in cross-sectional studies of people belonging to different age-groups, and applied the method to new data from a study of apolipoprotein E genotypes (apoE) in 177 Danish centenarians and data from a study of 40-year-old Danish men. Twenty-one percent of the centenarians were epsi...

When designing robust controllers, H-in nity synthesis is a common tool to use. The controllers that result from these algorithms are typically of very high order, which complicates implementation. However, if a constraint on the maximum order of the controller is set, that is lower than the order of the (augmented) system, the problem becomes nonconvex and it is relatively hard to solve. These...

Genotoxic activities of a series of commercially purchased 1,N6-ethenoadenosine (epsilon-Ado) and epsilon-deoxyadenosine (epsilon-dAdo) derivatives were assessed using the sister chromatid exchange (SCE) assay in murine spleen lymphocytes in vitro. Of the epsilon-Ado adducts evaluated for SCE induction epsilon-ATP and epsilon-dATP were highly active (5x baseline) SCE inducers over a concentrati...

In this work we introduce a relaxed version of the constant positive linear dependence constraint qualification (CPLD) that we call RCPLD. This development is inspired by a recent generalization of the constant rank constraint qualification from Minchenko and Stakhovski that was called RCR. We show that RCPLD is enough to ensure the convergence of an augmented Lagrangian algorithm and asserts t...

Early work in augmented reality grew out of virtual reality research domains. These initial augmented reality systems applied the same methods and technology to solve what at first appeared to be a similar problem: correctly render a scene of virtual objects as the user changes viewpoint in the world. This is indeed similar for augmented and virtual reality systems. In virtual reality systems o...

We review the current status of calculations of the two pion decays of the kaon using the firstprinciples methods of lattice gauge theory and the significant challenges that these calculations pose. While a calculation with controlled errors at even the 10-20% level has not yet been performed, present results suggest that such a calculation of the real and imaginary parts of the ∆I = 3/2 amplit...

We present in this paper an iterative algorithm to solve constraint forces for haptic interactive simulation. The haptic forces are induced by interaction with guidance virtual fixtures having forbidden regions. In general, a haptic rendering based on an explicit formulation of the constraint forces (with virtual springs) can lead to severe numerical stability problems in case of hard constrain...

vspace{0.2cm}In this paper, we design a data structure for the following problem. Let $pi$ be an $x$-monotone trajectory with $n$ vertices in the plane and $epsilon >0$. We show how to preprocess $pi$ and $epsilon$ into a data structure such that for any horizontal query segment $Q$ in the plane, one can quickly determine the minimal continuous fraction of $pi$ whose Fr{'e}chet and Hausdo...

Modern ports face significant challenges as strategic nodes of global supply chains, being responsible for the coordination inbound and outbound flows at deep-sea in hinterland transport corridors. Digitization adoption disruptive technologies can help to tide over operational challenges. Automated Ground Vehicles (AGVs) are an integral part operations many modern ports, especially inside conta...

The use of random samples to approximate properties of geometric configurations has been an influential idea for both combinatorial and algorithmic purposes. This chapter considers two related notions— -approximations and -nets—that capture the most important quantitative properties that one would expect from a random sample with respect to an underlying geometric configuration. An example prob...