Although the exact details are disputed, it is well established that propagating waves of increased intracellular free Ca2+ concentration arise from a positive feedback or autocatalytic mechanism whereby Ca2+ stimulates its own release. Most previous modeling of the propagation of Ca2+ waves has assumed that the sites of autocatalytic Ca2+ release, the activation sites, are homogeneously distri...

A quantitative understanding of microbial growth on mixtures of substrates is of considerable biological and practical interest. Microbes growing in mixed-substrate environments display a rich spectrum of dynamics. The goal of this work is to show that it is possible to capture these dynamics by a judicious choice of only a few physiological variables. The central idea of the mathematical model...

The main aim of this study was determination of thermo- radio- and photostability ofperindopril tert-butyloamine (PER) therefore the efficiency and safety of the therapy could bemaintained.A chromatographic method (RP-HPLC) had been validated before use to determinePER loss. The evaluation of stability properties of PER in solid state under the influence ofisothermal condition, relative humidit...

A CRISPR–Cas13a-powered autocatalytic cleavage circuit (CRISPR-ACC) for ultrasensitive and specific detection of a circadian clock gene was developed.

The autocatalytic reaction system with a small number of molecules is studied numerically by stochastic particle simulations. A novel state due to fluctuation and discreteness in molecular numbers is found, characterized as an extinction of molecule species alternately in the autocatalytic reaction loop. Phase transition to this state with changes of the system size and flow is studied, while a...

Microtubule asters - radial arrays of microtubules organized by centrosomes - play a fundamental role in the spatial coordination of animal cells. The standard model of aster growth assumes a fixed number of microtubules originating from the centrosomes. However, aster morphology in this model does not scale with cell size, and we recently found evidence for non-centrosomal microtubule nucleati...

We determine conditions under which a random biochemical system is likely to contain a subsystem that is both autocatalytic and able to survive on some ambient 'food' source. Such systems have previously been investigated for their relevance to origin-of-life models. In this paper we extend earlier work, by finding precisely the order of catalysation required for the emergence of such self-sust...