we describe a rare case of laryngeal fasciitis ossificans. a 58-year-old man presented with hoarseness and a nodule was found in the larynx. excisional biopsy was performed, and follow-up laryngoscopy showed complete resolution of this reactive lesion, and normal laryngeal function. the 0.6 cm diameter nodule was well circumscribed and histologically, the lesion was composed of uniform woven bo...

Background Antisynthetase syndrome (ASSD) is an autoimmune disease characterized by the presence of antiaminoacyl tRNA-synthetase antibodies (ARS) and clinical manifestations that may include interstitial lung (ILD), myositis, arthritis, Raynaud´s phenomenon (RP), fever mechanic’s hands (MHs). The incidence rate unknown no population epidemiological studies have been published. Objectives To de...

Statins, also known as 3-hydroxy-3-methylglutaril-CoA reductase inhibitors, are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Although they are generally considered safe, some serious adverse effects, such as myositis, myopathy, and rhabdomyolysis can rarely occur. Furthermore, recent data from long-term follow-up on patients who have been taking statins...

SEE HOHLFELD AND SCHULZE-KOOPS DOI101093/BRAIN/AWW053 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Inclusion body myositis and T cell large granular lymphocytic leukaemia are rare diseases involving pathogenic cytotoxic CD8+ T cells. After encountering four patients with both disorders, we prospectively screened 38 patients with inclusion body myositis for the presence of expanded large granula...

The idiopathic inflammatory myopathies (IM) represent a heterogeneous group of autoimmune diseases, of which dermatomyositis (DM), polymyositis (PM), and sporadic inclusion body myositis (IBM) are the most common. The crucial role played by tumor necrosis factor alpha (TNFα) in the IM has long been recognized. However, so far, 18 other members of the TNF superfamily have been characterized, and...

Mixed connective tissue disorder (MCTD) is a multisystem disease with overlapping features of other autoimmune diseases, such as systemic lupus erythematosus (SLE), myositis, rheumatoid arthritis, and scleroderma. MCTD presents with a distinctive antibody in serum known as U1-ribonucleoprotein (RNP). MCTD is quite rare as compared to other connective tissue disorders like SLE, systemic sclerosi...

A 42-year-old man had a 2-year history of progressive asymptomatic left calf enlargement. MRI showed diffuse swelling of left calf muscles (figure, A and B); biopsy displayed neurogenic changes (figure, C and D). Electrodiagnostic examination results were compatible with left chronic S1 radiculopathy and lumbosacral MRI revealed an ipsilateral L5-S1 disc protrusion encroaching on the foraminal ...

The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dermatomyositis, polymyositis, and autoimmune necrotizing myopathy. IBM is the most common IIM after age 50 years. Muscle histopathology shows endomysial inflammatory exudates surrounding and invading nonnecr...

Background Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune diseases (AID) characterized by muscle inflammation and weakness, often accompanied with other organ involvement, such as skin rash or interstitial lung disease (ILD). Myositis specific (MSA) myositis associated antibodies (MAA) can be detected in approximately 60% patients IIM. Besides, antibody titers ...