UNLABELLED A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene, which encodes a protein targeted by triazole antifungal drugs. Whole-genome sequencing (WGS) was performed for high-resolution single-n...

Invasive aspergillosis due to azole-resistant Aspergillus fumigatus is difficult to manage. We describe a case of azole-resistant invasive aspergillosis in a female bottlenose dolphin, who failed to respond to voriconazole and posaconazole therapy. As intravenous therapy was precluded, high dose posaconazole was initiated aimed at achieving trough levels exceeding 3 mg/l. Posaconazole serum lev...

fungal pathogen in humans, causes diseases varying from superficial mucosal complaints to life-threatening systemic disorders. Coincident with the increased use of antifungal drugs, the incidences of drug resistance have also increased. In recent years, the development of multidrug resistance in clinical isolates has challenged effective treatment of the infections. Specifically, the extensive ...

1 Primary treatment with amphotericin B or quickly switching from azoles to amphotericin B seems to be mandatory for good clinical outcome. There is no evidence of a clear correlation between the MICs of amphotericin B and outcome of treatment , but high MICs should be taken into consideration for antifungal alternatives. 7 The combination of amphotericin B with caspofungin could have been bene...

Aim: To evaluate the capacity of hematoporphyrin monomethyl ether 23 (HMME) in the presence of light to cause photodynamic inactivation (PDI) of C. 24 albicans. Materials & methods: HMME photoactivity was evaluated against 25 azole-susceptible and resistant C. albicans. The mechanisms by which PDI of C. 26 albicans occurred were also investigated. Results: HMME-mediated PACT caused a 27 dose-de...

A series of azole derivatives (5a-d, 6a-d and 7a-d) have been synthesized from (2,4,5-triphenyl-imidazole-1-yl)-acetic acid hydrazide under various reaction conditions. Elemental analysis, IR, H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. All the synthesized azole derivatives have been investigated for their antiinflammatory, antibacterial and antifung...

A Candida glabrata calcineurin mutant exhibited increased susceptibility to both azole antifungal and cell wall-damaging agents and was also attenuated in virulence. Although a mutant lacking the downstream transcription factor Crz1 displayed a cell wall-associated phenotype intermediate to that of the calcineurin mutant and was modestly attenuated in virulence, it did not show increased azole ...

Stabilization of copper( ii ) azide by application various nitrogen-rich azole ligands resulted in a series powerful energetic coordination compounds with desired properties for primary explosives.

We report on the first cloning and nucleotide sequencing of an ERG11 allele from a clinical isolate of Candida kefyr cross-resistant to azole antifungals. It was recovered from a stem cell transplant patient, in an oncohematology unit exhibiting unexpected high prevalence of C. kefyr. Two amino acid substitutions were identified: K151E, whose role in fluconazole resistance was already demonstra...