Breast cancer in women is a major health problem worldwide, with approximately 1.3 million women was estimated to be diagnosed with breast cancer in 2008 (Smith et al., 2012; Bray et al., 2013). Breast cancer is a heterogeneous disease in terms of gene expression, morphology, clinical course, and response to treatment. Therapeutic options for this breast cancer include surgery, adjuvant chemoth...

Mps1-dependent spindle assembly checkpoint (SAC) signaling delays anaphase entry until all chromosomes have been correctly attached to the mitotic spindle (Foley and Kapoor, 2013). Knl1 is the kinetochore localized binding partner for the SAC proteins Bub1, BubR1, and Bub3 (Kiyomitsu et al., 2007). Phosphorylation of Knl1 by Mps1 is a prerequisite for the interaction of Bub1 and Bub3 with Knl1 ...

We have reviewed the renormalization procedure used in the unitarized coupled-channel model of Romanets et al. (Phys Rev D 85:114032, 2012), and its impact in the C = 1, S = − 2, and I = 0 sector, where five (∗) c states have been recently observed by the LHCb Collaboration. The meson-baryon interactions used in the model are consistent with both chiral and heavy-quark spin symmetries, and lead...

1. Ku CS, Polychronakos C, Tan EK et al. A new paradigm emerges from the study of de novo mutations in the context of neurodevelopmental disease 2012, http://dx.doi.org/10.1038/mp.2012.58. 2. Lee JH, Huynh M, Silhavy JL et al. De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly. Nat Genet 2012: 44 (8): 941–945. 3. Sheppard K, Kinross KM, Solomon B Pear...

Arnold-Chiari malformations (ACM) represent a constellation of related congenital anomalies at the base of the brain. ACM is a very rare disorder with displacement of the cerebellar tonsils caudally into the foramen magnum. To date, the cause of this malformation is unknown, however, there is some evidence for a defect of the paraxial mesoderm resulting in a shallow posterior cranial fossa and ...

The rice bran or outer layer of the rice grain contains a number of micronutrients and valuable phytochemicals. Several studies have shown that pigmented rice bran contains higher amounts of beneficial phytochemicals such as phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, phytic acid, free fatty acids and methyl ester derivatives (Leardkamolka...

Recently, the glycerophosphodiesterase EDI3 (GPCPD1) has been shown to represent a key factor of choline metabolism that mediates tumor cell migration, adhesion and spreading (Stewart et al., 2012; Lesjak et al., 2014). EDI3 cleaves glycerophosphocholine to choline and glycerol-3-phosphate (Marchan et al., 2012). Choline is further metabolized by choline kinase alpha (CHKA) that generates phosp...

Volume 47 of Advances in Ecological Research is the second in a series of three that address awide-ranging theme in contemporary ecology: global change in multispecies systems. In the previous volume, the ecological consequences of various environmental stressorswere explored ( JacobandWoodward, 2012), including several of the different components of climate change (Ledger et al., 2012; Meerhof...